摘要
目的:探讨高度近视眼黄斑劈裂患者的黄斑区脉络膜容积(MCV)的特征及其临床意义。方法:横断面研究。纳入2016年1月至2020年12月于北京大学人民医院眼科门诊就诊的39例(39只眼)高度近视眼黄斑劈裂患者作为黄斑劈裂组,年龄(59.3±6.7)岁,其中男性18例,女性21例;选取年龄、性别、屈光度数匹配但无黄斑并发症的高度近视眼患者39例(39只眼)作为对照组。收集两组患者屈光度数、眼轴长度和最佳矫正视力,并通过加强深度扫描模式的相干光层析成像术(EDI-OCT)获取黄斑中心凹多个部位的视网膜及脉络膜厚度数据,采用MATLAB软件计算该区域的视网膜容积(MRV)及MCV。并根据OCT特征,将黄斑劈裂组进一步分为内层劈裂亚组和外层劈裂亚组,分析2个亚组的MCV特征。计量资料采用独立样本t检验,并进行Pearson相关性分析及线性回归分析。结果:黄斑劈裂组和对照组黄斑中心凹下脉络膜厚度分别为(74.9±59.3)和(155.6±47.1)μm,MCV分别为(2.3±0.8)和(5.3±1.0)mm 3,差异均有统计学意义(t=-6.649,-15.229;P<0.01)。两组患者黄斑中心凹下脉络膜厚度与视网膜厚度无相关性(r=0.103,0.214;P>0.05),但两组MCV与MRV都具有相关性,黄斑劈裂组黄斑区MCV与MRV呈负相关(y=-2.90 x+18.48;r2=0.47,P=0.01),对照组黄斑区MCV与MRV呈正相关(y=0.74 x+2.02;r2=0.64,P=0.01)。黄斑劈裂组的最佳矫正视力与MCV呈正相关(r=0.677,P<0.05)。内层(19只眼)及外层(15只眼)黄斑劈裂亚组的MCV分别为(2.80±0.81)和(1.92±0.27)mm 3,差异有统计学意义(t=4.610,P<0.05)。结论:高度近视眼黄斑劈裂患者的黄斑区MCV明显变小,这可能与该疾病的发病机制相关;MCV越小,视网膜外层血供来源越匮乏,黄斑劈裂越严重,MRV越大。
Objective To study the macular choroidal volume(MCV)of patients with highly myopic foveoschisis and its clinical value.Methods In this cross-sectional study,39 outpatients(39 eyes)with highly myopic foveoschisis were included from January 2016 to December 2020 in Peking University People′s Hospital,including 18 males and 21 females.Their age was(59.3±6.7)years old.Thirty-nine highly myopic patients(39 eyes)with no macular complications were enrolled as control group.The age,gender,and refractive error were matched between two groups.Medical history information and eye examination information including refractive error,axial length and best corrected visual acuity were recorded.All patients had undergone high-resolution enhanced depth imaging optical coherence tomography to measure the retinal and choroidal thickness of multiple parts of the macular zone.According to the image characteristics,myopic foveoschisis patients were divided into the inner and outer myopic foveoschisis subgroups,and the MCV characteristics were analyzed.The independent sample t test,Pearson correlation analysis and linear regression analysis were used.Results The subfoveal choroidal thickness was(74.9±59.3)and(155.6±47.1)μm,and MCV was(2.3±0.8)and(5.3±1.0)mm3 in the foveoschisis group and the control group,respectively.The differences were statistically significant(t=-6.649,-15.229;P<0.01).Although no correlation was found between subfoveal choroidal thickness and central foveal thickness in both groups(r=0.103,0.214;P>0.05),MCV was negatively correlated with macular retinal volume(MRV)in the foveoschisis group(y=-2.90x+18.48;r2=0.47,P=0.01).In the control group,there was a positive correlation between MCV and MRV(y=0.74x+2.02;r2=0.64,P=0.01).The best corrected visual acuity was positively associated with MCV in patients with foveoschisis(r=0.677,P<0.05).The MCV of inner(19 eyes)and outer(15 eyes)foveoschisis subgroups was(2.80±0.81)and(1.92±0.27)mm3,and the difference was statistically significant(t=4.610,P<0.05).Conclusions The MCV significantly decreased in patients with highly myopic foveoschisis.The smaller the MCV,the scarcer the blood supply of the outer retina,the more serious the foveoschisis,and the larger the MRV.
作者
徐琼
王凯
瞿佳
赵明威
Xu Qiong;Wang Kai;Qu Jia;Zhao Mingwei(Department of Ophthalmology,Peking University People′s Hospital,Eye Diseases and Optometry Institute,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases,College of Optometry,Peking University Health Science Center,Beijing 100044,China;Eye Hospital of Wenzhou Medical University,National Clinical Research Center for Ocular Diseases,Wenzhou 325027,China)
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2021年第6期419-425,共7页
Chinese Journal of Ophthalmology
基金
国家重点研发计划资助(2020YFC2008200)
国家自然科学基金(82000928)
北京大学人民医院院内发展基金(RDY2019-38)。
作者简介
通信作者:赵明威,Email:dr_zhaomingwei@163.com。
