摘要
目的探讨盐酸舍曲林片联合利培酮对残留型精神分裂症脑保护作用。方法选取2016年6月—2019年6月在安徽省阜阳市第三人民医院确诊并治疗的70例残留性精神分裂症患者,按照随机数字表法将其分为联合治疗组(35例,盐酸舍曲林片、利培酮治疗)和对照组(35例,利培酮治疗)。比较两组治疗前和治疗后6个月、12个月阳性与阴性症状量表(PANSS)阳性、阴性及总分评分、简易智力量表(MMSE)情况。结果两组治疗后6个月PANSS阳性、阴性、总评分低于治疗前,MMSE评分高于治疗前(P<0.05)。治疗后12个月两组PANSS阳性、阴性、总评分低于治疗6个月和治疗前,MMSE评分高于治疗后6个月和治疗前(P<0.05)。联合治疗组治疗后6个月PANSS阳性以及总分低于对照组,MMSE评分高于对照(P<0.05);联合治疗组治疗后12个月PANSS阳性、阴性、总评分低于对照组,MMSE评分高于对照组(P<0.05)。结论盐酸舍曲林片联合利培酮能有效降低残留型精神分裂症患者PANSS评分、升高MMSE评分,对残留型精神分裂症患者具有脑保护作用。
Objective To investigate the protective effect of Sertraline Hydrochloride Tablets combined with Risperidone on the brain of residual schizophrenia.Methods A total of 70 patients with residual schizophrenia who were diagnosed and treated in the Third People’s Hospital of Fuyang City,Anhui Province from June 2016 to June 2019 were selected and divided into two groups according to random number table method:the combined treatment group(35 cases,Sertralin Hydrochloride Tablet and Risperidone treatment)and the control group(35 cases,Risperidone treatment).The positive and negative symptom scale(PANSS)positive,negative and total scores and the simple mental strength scale(MMSE),before treatment and six months and 12 months after treatment were compared.Results Six months after treatment,PANSS positive,negative and total scores were lower in both groups than that before treatment,while MMSE score was higher than that before treatment(P<0.05).At 12 months after treatment,PANSS positive,negative and total scores were lower than those before treatment and after six months of treatment,while MMSE score was higher than those before and after six months of treatment(P<0.05).At six months after treatment,PANSS positive and total score in the combined treatment group were lower than those in the control group,while MMSE score was higher than that in the control group(P<0.05).At 12 months after treatment,the positive,negative and total scores of PANSS in the combined treatment group were lower than those in the control group,while the MMSE score in the combined treatment group was higher than that in the control group(P<0.05).Conclusion Sertraline Hydrochloride Tablets combined with Risperidone can effectively reduce PANSS score and increase MMSE score in patients with residual schizophrenia,and have a brain protective effect on patients with residual schizophrenia.
作者
储伟伟
夏梦君
孙亮
CHU Weiwei;XIA Mengjun;SUN Liang(Psychiatric Ward 14,the Third People’s Hospital of Fuyang City,Anhui Province,Fuyang236015,China)
出处
《中国医药导报》
CAS
2021年第18期127-130,共4页
China Medical Herald
基金
安徽省重点研究与开发计划项目(1804h08020263)。
关键词
盐酸舍曲林
利培酮
残留型精神分裂症
脑保护
Sertraline Hydrochloride Tablets
Risperidone
Residual schizophrenia
Brain protection
