摘要
目的:探讨利培酮在慢性精神分裂症维持治疗中的临床疗效。方法:选取在本院长期住院的110名慢性精神分裂症患者,按单双号随机分为两组,每组各55人,一组换用利培酮,另一组延用氯丙嗪。研究过程中因脱落,最终利培酮组有50人,氯丙嗪组有51人完成全部研究。用阳性和阴性症状评定量表(PANSS)评价疗效;用副反应量表(TESS)评定药物不良反应;统计病情复发次数。结果:经过3年维持治疗,在PANSS量表评分方面,两组均呈减分趋势,两组间总分无显著差异(P﹥0.05),其中利培酮组对阴性症状的改善优于氯丙嗪组(P﹤0.05)。两组间病情复发的次数差异不明显(P﹥0.05)。经TESS量表评定显示两组患者有13个项目出现不良反应,利培酮组在活动减退、嗜睡、肝功能异常、震颤、口干、便秘、流涎等方面的不良反应低于氯丙嗪组,但体重增加比后者高,两组间差异具有显著性(P﹤0.05)。结论:利培酮在慢性精神分裂症维持治疗方面的疗效和氯丙嗪相当,不良反应的发生率低于氯丙嗪,与氯丙嗪相比利培酮更适合于慢性精神分裂症的维持治疗。
Objective： To explore clinical therapeutic efficacy of risperidone in maintenance therapy for patients with chronic schizophrenia.Methods： 110 long-stay inpatients with chronic schizophrenia were divided into risperidone group（55 cases） and chlorpromazine（55 cases） according to the even or odd number.Because of falling out in the course of the study,50 patients in risperidone group and 51 patients in chlorpromazine group completed the whole study,finally.Positive and negative symptom scale（PANSS） was used to assess the therapeutic efficacy and treatment emergent symptom scale（TESS） was used to evaluate the side effects.Further,recurrence frequency was statistically analyzed.Results： After three years of maintenance therapy,the PANSS scores of the two groups showed a tendency of deduction,and there was no significant difference in total score between the two groups（P 0.05）.Risperidone group had a better effect on improving the negative symptoms than chlorpromazine group（P 0.05）,while no obvious difference in the recurrence frequency was observed between two groups（P 0.05）.The assessment of TESS showed that the patients of the two groups had side effects in 13 items,and risperidone group had lower side effects than chlorpromazine group in hypoactivity,sleepiness,abnormal liver function,tremor,dry mouth,constipation and salivate,however,weight gain in risperidone group was significant higher than that of chlorpromazine group（P ﹤ 0.05）.Conclusions： Risperidone has an equal therapeutic efficacy with chlorpromazine in the maintenance therapy of chronic schizophrenia.The incidence of side effects of risperidone is lower than that of chlorpromazine.Compared with chlorpromazine,risperidone is more suitable for the maintenance therapy of chronic schizophrenia.
出处
《中国民康医学》
2013年第17期4-6,共3页
Medical Journal of Chinese People’s Health
关键词
利培酮
氯丙嗪
慢性精神分裂症
维持治疗
Risperidone
Chlorpromazine
Chronic Schizophrenia
Maintenance therapy
