摘要
目的:分析老年颅脑手术麻醉诱导中使用不同剂量舒芬太尼结合依托咪酯的应用效果。方法:选取自2019年1月至2020年12月间在某院接受颅脑手术的80例老年患者作为研究主体,基线分组采用系统随机抽样法,即对照组和观察组,每组40例。对照组采用0.3μg/kg舒芬太尼+0.2μg/kg依托咪酯方法麻醉,观察组采用0.5μg/kg舒芬太尼+0.2μg/kg依托咪酯方法麻醉,通过对比两组患者各个时间点的血流动力学指标和不良反应发生情况,分析麻醉诱导效果。结果:观察组患者T2、T3、T4、T5、T6时间点的血流动力学指标结果与T1之间的差异并不具有统计学意义(P>0.05),而对照组患者T4、T5、T6时间点的HR指标明显高于T1,T6时间点的DBP和SBP水平较T1高,差异有统计学意义(P<0.05);观察组患者不良反应发生率是2.50%(1/40),较对照组20.00%(8/40)更低,差异有统计学意义(P<0.05)。结论:针对老年颅脑手术患者,临床给予0.5 ug/kg舒芬太尼结合依托咪酯进行麻醉诱导,可以有效降低药物对机体血流动力学指标的影响性,不良反应少,安全性高,值得在当前临床中加以推广。
Objective:To analyze the application value of different doses of sufentanil combined with etomidate in induction of anesthesia in elderly craniocerebral surgery.Methods:80 elderly patients who underwent craniocerebral surgery in our hospital from January 2019 to December 2020 were selected as the main body of the study.The baseline groupings were grouped by a systematic random sampling method,namely the control group and the observation group,with 40 cases in each group.The control group was anesthetized with 0.3μg/kg sufentanil+0.2μg/kg etomidate,and the observation group was anesthetized with 0.5μg/kg sufentanil+0.2μg/kg etomidate,comparing the two groups of patients of the hemodynamic indicators and adverse reactions at the time point,analyzing the effect of anesthesia induction.Results:The difference between the hemodynamic index results at T2,T3,T4,T5,and T6 in the observation group and T1 was not statistically significant(P>0.05),while the control group of the HR index at time point of T4,T5,T6 was significantly higher than that at T1,and the DBP and SBP levels at time T6 were higher than that at T1,and the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 2.50%(1/40),which was lower than the data of the control group 20.00%(8/40),and the difference was statistically significant(P<0.05).Conclusion:For elderly patients undergoing craniocerebral surgery,clinical administration of 0.5 ug/kg sufentanil combined with etomidate for anesthesia induction can effectively reduce the drug’s influence on the body’s hemodynamic indicators,with few adverse reactions and high safety.It is worthy of promotion in the current clinical practice.
作者
隋平
SUI Ping(Department of Anesthesiology,Zhuanghe Central Hospital,Dalian,Liaoning Province 116400 China)
出处
《中国药物滥用防治杂志》
CAS
2021年第2期192-195,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
不同剂量
舒芬太尼
依托咪酯
老年
颅脑手术
麻醉诱导
Different doses
Sufentanil
Etomidate
Elderly
Craniocerebral surgery
Induction of anesthesia
作者简介
隋平(1976.01-),女,辽宁庄河人,本科,副主任医师,主要研究方向:麻醉。
