摘要
目的观察不同剂量舒芬太尼复合依托咪酯乳剂静脉诱导用于老年患者喉罩插入的临床效果,探讨舒芬太尼的合适剂量。方法喉罩全麻下行择期手术的老年患者75例,年龄>65岁,ASAI或Ⅱ级,随机均分为五组,插入喉罩前分别静注舒芬太尼0.05μg/kg(Ⅰ组)、0.1μg/kg(Ⅱ组)、0.15μg/kg(Ⅲ组)、0.2μg/kg(Ⅳ组)和0.25μg/kg(Ⅴ组)后,静注依托咪酯乳剂0.2mg/kg。插入喉罩时,若患者出现吞咽、呛咳、屏气、喉痉挛等气道反应或肢体运动,则认为条件不满意;无相应反应则为满意。结果Ⅰ～Ⅴ组插入喉罩满意的例数分别为0、2、7、12、15例。舒芬太尼ED50为0.15μg/kg,95%CI为0.14～0.17μg/kg;ED95为0.23μg/kg,95%CI为0.20～0.28μg/kg。结论老年患者应用舒芬太尼0.23μg/kg联合依托咪酯乳剂0.2mg/kg插入喉罩满意度较好,对血流动力学影响小。
Objective To determine the optimal dose of sufentanil, co-administered with etomidate-lipuro 0.2mg/kg, in the insertion of laryngeal mask airway in elderly patients. Methods Seventy-five elderly patients, ASA I-II, scheduled for selective minor surgery were randomly received etomidate-lipuro 0.2 mg/kg and one of the five dosages （0. 05,0. 1,0.15,0.2 or 0.25 μg/kg） of sufentanil. The successful insertion of LMA was defined as the absence of swallowing, coughing, breath holding, laryngospasm and extremity movements after LMA insertion. Results For each of the following dosages （0.05, 0. 1, 0.15, 0. 2 and 0. 25 μg/kg） of sufentanil, the successful number of IrMA insertion cases was 0, 2, 7, 12 and 15, respectively. ED50 of sufentanil was 0.15 μg/kg （95%CI 0.14 0. 17 μg/kg） and ED95 of sufentanil was 0.23 μg/kg （95%CI 0. 20- 0.28 μg/kg）. Conclusion The optimal dose of sufentanil was 0.23μg/kg in LMA insertion in elderly patients when combined with 0.2 mg/kg etomidate-lipuro.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2012年第6期555-556,共2页
Journal of Clinical Anesthesiology
关键词
舒芬太尼
喉罩
量效关系
老年
Sufentanil
Laryngeal mask airway
Dose-response relationship, drug
Elderly
作者简介
通信作者：陈彦青，Email：sxd605@21cn．com
