摘要
目的探讨局部光动力疗法(PDT)治疗尖锐湿疣(CA)时引起疼痛的相关因素,并提出减轻疼痛的对策。方法选取2016年12月至2019年12月山东省立第三医院诊治的150例行PDT治疗的CA患者作为研究对象。采用视觉模拟评分法(VAS)对所有研究对象进行疼痛评估,按照疼痛程度分为疼痛组(n=98)和无疼痛组(n=52)。收集人口统计学资料、疾病资料、手术资料,并分析其与疼痛的相关性。结果单因素分析结果显示,性别因素、皮损部位、皮损面积、是否首次治疗、光源类型、止痛方式在疼痛组和非疼痛组之间的差异具有统计学意义(P<0.05);而年龄、体重指数、嗜烟、嗜酒、高血压、糖尿病、皮损数量在两组间差异无统计学意义(P>0.05)。Logistic多元回归分析显示,男性、皮损部位为尿道口/肛周、皮损面积≥1cm^(2)、首次治疗、光源类型为红光、止痛方式为表面麻醉均是治疗时疼痛的独立危险因素(P<0.05),这些因素分别使治疗时疼痛危险增加1.536倍、2.042倍、1.520倍、1.263倍、1.523倍和3.360倍。结论男性、皮损部位为尿道口/肛周、皮损面积≥1cm^(2)、首次治疗、光源类型为红光、止痛方式为表面麻醉均是PDT治疗CA引起疼痛的危险因素。PDT治疗时需综合考虑危险因素、临床实际情况及患者自身条件,以选取最佳治疗方案。
Objective To explore the related factors of pain caused by local photodynamic therapy(PDT)in the treatment of condyloma acuminatum(CA),and put forward the countermeasures for pain relief.Methods 150 CA patients receiving PDT treatment in the Shandong Provincial Third Hospital from December 2016 to December 2019 were selected as the research subjects.Visual analogue scale(VAS)was used to assess the pain of all subjects,and they were divided into pain group(n=98)and pain-free group(n=52).Demographic data,disease data,and surgical data were collected and analyzed for their correlation with pain.Results Univariate analysis showed that gender factors,lesion site,lesion area,whether or not the first treatment,light source type,analgesic methods were significantly different between the pain group and the pain-free group(P<0.05).There were no significant differences in age,body mass index,smoking and alcohol addiction,hypertension,diabetes and the number of skin lesions between the two groups(P>0.05).Logistic multiple regression analysis showed that male,ureteral/perianal lesion site,lesion area≥1 cm~2,first treatment,red light as the light source,analgesic method of surface anesthesia were all independent risk factors for pain during treatment(P<0.05).These factors increased the risk of pain by 1.536,2.042,1.520,1.263,1.523 and 3.360 times,respectively.Conclusions Male,urethral orificium/perianal lesions,skin lesion area≥1 cm~2,first treatment,red light as the light source,analgesic method of surface anesthesia were all risk factors for pain induced by PDT treatment of CA.In the treatment of PDT,risk factors,clinical conditions and patients′own conditions should be considered comprehensively to select the best treatment plan.
作者
皮庆友
李晶
孔泽琳
陈璐
PI Qingyou;LI Jing;KONG Zelin;CHEN Lu(Department of Dermatology,Shandong Provincial Third Hospital,Jinan 250031,Shandong,China)
出处
《中国性科学》
2021年第4期145-147,共3页
Chinese Journal of Human Sexuality
关键词
尖锐湿疣
光动力疗法
疼痛
危险因素
Condyloma acuminatum
Photodynamic therapy
Pain
Risk factors
作者简介
通讯作者:皮庆友,E-mail:piqingyou@163.com。
