摘要
癌症的标志性特征是对凋亡的抵抗力,同时促凋亡信号的丢失和抗凋亡信号的获得均有助于肿瘤发生与发展。诱导恶性肿瘤细胞凋亡是关于癌症最具挑战性的任务之一,近年来,研究人员越来越关注天然产物来调节细胞凋亡信号通路。姜黄素(Curcumin,Cur)具有确切的抗肿瘤疗效,已广泛用于各种临床前研究,诱导肿瘤细胞凋亡是姜黄素抗肿瘤作用的重要机制。姜黄素可通过调控多个靶点及细胞信号通路介导肿瘤细胞凋亡,本文综述了姜黄素诱导细胞凋亡相关机制,有望为Cur应用于临床提供理论基础。
A hallmark of cancer is resistance to apoptosis,with both the loss of proapoptotic signals and the gain of antiapoptotic mechanisms contributing to tumorigenesis and development.As inducing apoptosis in malignant cells is one of the most challenging tasks regarding cancer,researchers increasingly focus on natural products to regulate apoptotic signaling pathways.Curcumin(Cur)has definite anti-tumor efficacy and has been widely used in various preclinical studies.Inducing tumor cell apoptosis is an important mechanism of anti-tumor effect of curcumin.Curcumin could mediate tumor cell apoptosis by regulating multiple targets and cell signaling pathway.This article reviews the mechanism of curcumin induced apoptosis,which is expected to provide a theoretical basis for cur in clinical application.
作者
刘智丹
吕美怡
吴发印
LIUZhi-dan(The fifth affiliated hospital(Zhuhai)of Zunyi Medical University,Zhuhai,Guangdong,519100,China)
出处
《齐齐哈尔医学院学报》
2021年第4期327-331,共5页
Journal of Qiqihar Medical University
作者简介
通信作者:吴发印,Email:wufy0515@163.com。
