摘要
子宫内膜异位症是一种雌激素依赖性进展性疾病,该病的发生发展多与内膜细胞的自噬和凋亡机制相关。子宫内膜异位症患者通过抑制内膜细胞凋亡水平来保护细胞并促进细胞增殖,从而促进子宫内膜异位症发生。但自噬在子宫内膜异位症中是“敌”是“友”仍旧存在争议。低水平和高水平自噬在子宫内膜异位症病灶中都有观察到,并可通过不同的方式抑制凋亡进而促进子宫内膜异位症的发生发展。故子宫内膜异位症中自噬与凋亡的相互关系以及自噬的表达水平仍需不断探索。
Endometriosis is an estrogen-dependent progressive disease,the occurrence and development of the disease are mostly related to the autophagy and apoptosis mechanisms of endometrial cells.Patients with endometriosis promote the occurrence of endometriosis by inhibiting the level of apoptosis of endometriosis cells to protect cells and promote cell proliferation.However,the role of autophagy in endometriosis is still controversial.However,whether autophagy is an“enemy”or a“friend”in endometriosis is still controversial.Both low and high levels of autophagy have been observed in endometriosis lesions,and can promote the development of endometriosis via inhibiting apoptosis in different ways.Therefore,the relationship between autophagy and apoptosis in endometriosis and the expression level of autophagy still need to be explored continuously.
作者
丛慧芳
李阳
于洋
张天婵
CONG Huifang;LI Yang;YU Yang;ZHANG Tianchan(Department of Gynecology,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150001China;the Second Clinical Medical College of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin,150001China;Department of Traditional Chinese Medicine,Heilongjiang Academy of Chinese Medicine Sciences,Heilongjiang Province,Harbin150036,China)
出处
《中国医药导报》
CAS
2021年第10期35-38,共4页
China Medical Herald
基金
国家自然科学基金青年科学基金项目(81704113)
黑龙江中医药大学研究生创新科研项目(2019yjscx008)。
关键词
子宫内膜异位症
自噬
凋亡
分子机制
Endometriosis
Autophagy
Apoptosis
Molecular mechanism
作者简介
丛慧芳(1962-),女,博士,教授,主任医师,博士生导师,研究方向:中医药防治月经病、妊娠病、不孕症、多囊卵巢综合征等妇科杂病;通讯作者:张天婵(1983-),女,博士,副主任医师,研究方向:子宫内膜异位症、痛经、围绝经期综合症等疾病。
