摘要
细胞死亡方式包括细胞凋亡、细胞程序性坏死和细胞焦亡。细胞凋亡属于非炎症性细胞死亡方式,形态学不涉及细胞质、细胞膜的破裂。细胞程序性坏死和细胞焦亡在形态学上可表现为细胞质、细胞膜破裂,释放一系列炎性因子,引起炎性反应,属于炎症性细胞死亡方式。三者在形态学及发生机制上有所区别,但在某些方面又存在着联系。在某些疾病的发生过程中,并非仅出现一种细胞死亡方式。本文就3种细胞死亡方式的形态学改变、发生机制及三者间关系的研究进展作一综述。
Cell death includes apoptosis,necroptosis and pyroptosis.Apoptosis is the first discovered mode of cell death and belongs to non-inflammatory cell death,and its morphology involves no rupture of cytoplasm or membrane.But necroptosis and pyroptosis are demonstrated by rupture of cytoplasm and membrane in morphology,releasing a series of inflammatory factors,and causing inflammatory response,therefore,necroptosis and pyroptosis belong to inflammatory cell death.Apoptosis,necroptosis and pyroptosis are different in morphology and have different mechanisms,but they are related with each other in some respects,and exist in some diseases at the same time.This paper reviews the morphological changes and mechanisms of these three types of cell death and the relationships among them.
作者
郭双
邢栋
吕勃
GUO Shuang;XING Dong;LYU Bo(Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150081,China)
出处
《中华实用诊断与治疗杂志》
2021年第3期321-324,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
中国博士后科学基金(2017M61139)。
作者简介
通信作者:吕勃,E-mail:2855928554@qq.com。
