摘要
目的观察补肾益发汤对斑秃(AA)患者的治疗效果及患者血清γ-干扰素(IFN-γ)和白细胞介素-10(IL-10)表达水平的影响。方法60例AA患者均分为观察组与对照组,对照组患者于皮损处外用生发酊(2次/d)和卤米松软膏(1次/d,晚上涂抹),观察组患者在对照组的基础上给予口服中药补肾益发汤、每次200 mL、早晚餐后0.5 h各口服1次,2组疗程均为3个月;观察治疗前及治疗3个月时2组患者脱发面积、拉发实验,皮肤镜检查、血清IFN-γ、IL-10水平,比较2组患者的治疗效果及治疗期间的不良反应。结果治疗3个月时观察组患者的总有效率(93.33%)高于对照组(73.33%),差异有统计学意义(P<0.05);治疗后,观察组患者血清IFN-γ水平较治疗前降低,IL-10水平较治疗前升高,差异有统计学意义(P<0.05);且观察组变化高于对照组,差异有统计学意义(P<0.05);治疗期间,2组患者均无明显不良反应发生。结论补肾益发汤治疗AA的疗效好,其机制可能与补肾益发汤可调节患者细胞因子IFN-γ及IL-10水平有关。
Objective To observe the curative effect of bushenyifa decoction in the treatment of alopecia areata(AA)and its influence on the expression of serum interferon-gamma(IFN-γ)and interleukin-10(IL-10).Methods Sixty patients with AA were selected and randomly divided into the observation group and the control group.In each group,30 cases of the two groups were externally treated with raw tincture twice a day and halometasone ointment once per night used at the skin lesion,while,in addition,the observation group was given oral Chinese medicine bushenyifa decoction.The treatment course of both groups lasted for 3 months.The result of the hair loss area pulling test was observed before and after treatment,and then serum IFN-γand IL-10 levels were detected by dermoscopy,and the clinical efficacy was evaluated.Results Three months after treatment,the total effective rates of the observation group and the control group were 93.33%and 73.33%,respectively,with significant differences(P<0.05).Serum IFN-γlevel in the observation group was significantly lower than that before treatment(P<0.05),and serum IL-10 level was significantly higher than that before treatment(P<0.05).There was no significant difference in serum IFN-γand IL-10 expression between the two groups before treatment,while IFN-γexpression of serum in the observation group was significantly lower than that in the control group after treatment(P<0.05),and IL-10 expression of serum was significantly higher than that in the control group(P<0.05).Conclusion Bushenyifa decoction has definite therapeutic effect on AA,which may be related to the down-regulation of IFN-γand up-regulation of IL-10.
作者
吴然
黄增阳
狄伟
黄微
杨轩
黄静
陈恋
程远
文昌晖
唐挺
贾敏
WU Ran;HUANG Zengyang;DI Wei;HUANG Wei;YANG Xuan;HUANG Jing;CHEN Lian;CHENG Yuan;WEN Changhui;TANG Ting;JIA Min(Department of Dermatology,the First Affiliated Hospital of Guiyang University of Chinese Medicine,Guiyang 550001,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2021年第3期340-344,356,共6页
Journal of Guizhou Medical University
基金
贵州省科技合作计划项目[黔科合LH字(2016)7506]
贵阳市科技计划项目[筑科合同(2019)9-2-10]。
关键词
斑秃
干扰素Γ
白细胞介素10
补肾益发汤
临床疗效
alopecia areata(AA)
interferon-gamma(IFN-γ)
interleukin-10(IL-10)
bushenyifa decoction
curative effect
作者简介
通信作者:贾敏,E-mail:minjia0851@163.Com。
