摘要
目的探讨抗环瓜氨酸肽(CCP)抗体、类风湿因子(RF)、红细胞沉降率(ESR)在类风湿关节炎(RA)诊断中的价值。方法选取2016年8月至2019年8月治疗的RA患者106例(RA组),同时选取其他风湿病患者47例(非RA组)和健康体检者50例(对照组)作为对照,检测3组抗CCP抗体、RF和ESR水平。结果RA组抗CCP抗体和RF分别为(104.67±94.96)U/ml和(249.61±251.55)U/ml,明显高于非RA组和对照组(P<0.05);RA组ESR为(63.57±35.45)mm/h,明显高于对照组(P<0.05),而与非RA组比较差异无统计学意义(P>0.05);RA组DAS28指数≥3.2患者抗CCP抗体和RF分别为(157.69±78.99)U/ml和(325.41±89.55)U/ml,明显高于<3.2患者(P<0.05);RA组DAS28指数≥3.2和<3.2患者ESR水平比较差异无统计学意义(P>0.05);抗CCP抗体、RF与DAS28呈正相关(r=0.533和0.612,P<0.05),ESR与DAS28无明显相关性(r=0.122,P>0.05);抗CCP抗体、RF诊断RA的ROC曲线下面积分别为0.627和0.610,P<0.05,截断值分别为59.59 U/ml和84.28 U/ml,灵敏性分别为70.00%和62.00%,特异性分别为80.00%和50.00%。结论RA患者抗CCP抗体、RF和ESR水平升高,其中抗CCP抗体、RF与病情活动程度有一定关系,且有一定的诊断价值。
Objective To investigate the application value of anti-cyclic citrullinated peptide(CCP)antibody,rheumatoid factor(RF)and erythrocyte sedimentation rate(ESR)in diagnosis of rheumatoid arthritis(RA).Methods A total of 106 patients with RA who were treated in our hospital from August 2016 to August 2019 were enrolled as RA group,and the 47 patients with the other rheumatic diseases were enrolled as non-RA group,moreover,50 healthy subjects were enrolled as control group.The anti-CCP antibodies,and the levels of RF and ESR were detected and compared.Results The levels of anti-CCP antibody,RF and ESR in RA group were significantly higher than those in non-RA group and control group(P<0.05).however,there were no significant differences between RA group and non-RA group(P>0.05).The levels of anti-CCP antibodies and RF in patients with DAS28 index≥3.2 in RA group were significantly higher than those of patients with DAS28 index<3.2(P<0.05).There were no significant differences in ESR levels between the patients with DAS28 index≥3.2 and the patients with DAS28 index<3.2 in RA group(P>0.05).In addition the anti-CCP antibody and RF were positively correlated with DAS28(P<0.05),but ESR was not significantly correlated with DAS28(P>0.05).The area under ROC curve of anti-CCP antibody and RF diagnostic RA were 0.627 and 0.610,respectively(P<0.05),and the cut-off values were 59.59U/ml and 84.28 U/ml,the sensitivities were 70.00%and 62.00%,and the specificities were 80.00%and 50.00%,respectively.Conclusion The levels of anti-CCP antibody,RF and ESR are increased in patients with RA,in which,the anti-CCP antibody and RF are related to the degree of disease activity,which has a certain diagnostic value.
作者
王烈
黄金保
胡义忠
WANG Lie;HUANG Jinbao;HU Yizhong(Department of Clinical Laboratory,Chizhou Municipal People’s Hospital,Anhui,Chizhou 247100,China)
出处
《河北医药》
CAS
2021年第3期373-375,379,共4页
Hebei Medical Journal
关键词
抗环瓜氨酸肽抗体
类风湿因子
红细胞沉降率
类风湿关节炎
anti-cyclic citrullinated peptide antibody
rheumatoid factor
erythrocyte sedimentation rate
rheumatoid arthritis
