摘要
从不同类型原位凝胶的制备及质量标准进行概述,指出原位凝胶是一种具有给药方便、靶向性强、良好的药物缓控释性能等优点的新型给药方式,但基质的刺激性和毒性还未十分明确,其制备方法及质量控制缺乏严格、统一的标准,制备工艺多样化,质量不可控,所以国内外应加大研究力度,尽快达成原位凝胶质量标准共识,以期更多的原位凝胶剂能够成功研发上市并让广大患者受益。
In-situ gel is a new drug delivery method with the advantages of convenient delivery,strong targeting,good sustained and controlled drug release through surveying the preparations and quality standard of different types of in-situ gels.However,the irritation and toxicity of matrix were not clear,its preparation method and quality control lacked strict and unified standards,the preparation technology was diverse,the quality was uncontrollable,therefore,more efforts should be made at home and abroad to reach a consensus on the quality standard of in-situ gel as soon as possible,in the hope of making more successful researches,development of the product and benefiting from most of patients.
作者
韩胜男
李喜香
闫治攀
张志瑞
HAN Shengnan;LI Xixiang;YAN Zhipan;ZHANG Zhirui(School of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine)
出处
《西部中医药》
2021年第1期153-157,共5页
Western Journal of Traditional Chinese Medicine
关键词
原位凝胶
制备工艺
质量标准
综述
in-situ gel
preparation technology
quality standard
review
作者简介
韩胜男(1994—),女,在读硕士研究生。研究方向:中药制药工艺研究。;通讯作者:李喜香(1968—),女,硕士学位,主任中药师,硕士研究生导师。研究方向:中药新制剂研发。
