摘要
目的探讨巨噬细胞表型对子宫内膜异位症性不孕(EI)患者治疗效果及性激素水平的影响。方法39例EI患者卵巢中异位子宫内膜样本分离细胞,流式细胞术检测巨噬细胞表型(M1和M2型),比较M1型和M2型患者症状评分、性激素水平及疗效差异。结果39例EI患者中,22例为M1型,17例为M2型。治疗前后M1型患者症状评分、黄体生成素、卵泡雌激素、雌二醇水平均高于M2型患者(P<0.01),而抗苗勒管激素水平差异无统计学意义(P>0.05)。治疗前两组窦卵泡数差异无统计学意义(P>0.05),而治疗后M2型患者显著高于M1型患者(P<0.01)。M2型EI患者疗效优于M1型(P<0.01)。结论异位子宫内膜中M1型巨噬细胞为主的EI患者临床症状更明显、性激素水平更高、疗效较差。
Objective To study the effect ofmacrophage phenotypes on clinical efficacy and sex hormone in patients with endometriotic infertility(EI).Methods Macrophage phenotypes(M1 and M2)in isolated cells from endometriotic ovary samples were determined by flow cytometry in 39 EI women.Symptom score,sex hormone and clinical efficacy were compared between M1 and M2 groups.Results There were 22 M1 and 17 M2 subtypes.Symptom score and levels of luteinizing hormone,follicle stimulatine hormone and estradiol were higher in M1 subtype than in M2 subtype before and after therapy(P<0.01),while anti-mullerian hormone showed no statistical difference between two subtypes(P>0.05).Although antral follicle counting was comparable between two subtypes pretreatment(P>0.05),it was remarkably increased in M2 subtype posttreatment compared with M1 subtype(P<0.01).Therapeutic efficacy was better in M2 subtype than in M1 subtype(P<0.01).Conclusion There are obvious symptoms,high sex hormone levels and poor efficacy in EI patients with endometriotic M1 macrophage.
作者
陈捷
姜桂芳
黄国伟
CHEN Jie;JIANG Gui-fang;HUANG Guo-wei(Department of Obstetrics and Gynecology,Affiliated Shunde Hospital,Jinan University,Foshan 528305,China)
出处
《广东医科大学学报》
2021年第1期55-58,共4页
Journal of Guangdong Medical University
基金
佛山市卫生和计生局医学科研课题(No.20190303)。
作者简介
陈捷(1984-),女,学士,副主任医师;通信作者:黄国伟(1976-),男,本科,主任医师。
