摘要
目的:煮散和散剂在《古代经典名方目录(第一批)》中占比约1/3,具有十分重要的地位。明确粉碎过程中的制备工艺和粉碎粒度是煮散和散剂"遵古"开发的关键步骤。然而,古籍文献中对制备工艺和粉碎粒度的描述术语众多,且参数不明确。由于缺乏统一的粒度依据,已有研究结果未形成统一共识。本文以遵古考证和实验结果为依据,对煮散和散剂的粒度进行探讨。方法:对煮散和散剂的制备工艺和粉碎粒度进行遵古考证,结合2020年版《中国药典》粉末分级,对粉碎粒度提出规格建议。并以泻白散及当归补血汤为例考察粉碎粒度(4,10,24目)对煮散制备过程和所得汤剂的影响。结果:4目粒度与古代"麻豆大"相当,且4目粒度的泻白散及当归补血汤中指标成分的含量均最高,而50目粒度时颗粒太细,几乎无法进行过滤操作。结论:煮散和散剂的粒度规格建议为"粗末"为过一号筛(10目),"末"为过二号筛(24目),"细末"为过五号筛(80目),"如麻豆大"可选择过4目筛但不过10目筛的粗颗粒。
Objective: Powders and decocted powders account for about 1/3 in the Catalogue of Ancient Famous Classical Formulas(the First Batch),and have a very important position. Determination of preparation technology and particle size in the pulverization process is the key step in the research and development of powders and decocted powders following the original methods. However,there are many terms describing the preparation technology and particle size of powders and decocted powders in ancient Chinese medical books,and the parameters are not clear. Due to the lack of unified basis of particle size,the existing research results have not formed a uniform consensus. Based on ancient textual researches and experimental results,this article discusses the particle size of decocted powders and powders. Method: Through textual researches of the preparation technology and particle size of powders and decocted powders and powder classification in the 2020 edition of Chinese Pharmacopoeia,the specifications of pulverized particle size were suggested. In addition,Xiebaisan and Danggui Buxuetang were taken as examples to investigate the influence of different particle sizes(4,10,24 mesh)on the preparation process of decocted powders and the obtained decoction. Result: The particle size of 4 mesh was equivalent to that of ancient as big as hemp bean. The contents of index components in Xiebaisan and Danggui Buxuetang with particle size of 4 mesh were higher than that of 10 mesh and 24 mesh,but the particle size of 50 mesh was too fine to be filtered. Conclusion: The suggested particle sizes of powders and decocted powders are recommended as Cumo is the power through 10-mesh sieve,Mo is the power through 24-mesh sieve,Ximo is the power through 80-mesh sieve,as big as hemp bean is the power through 4-mesh sieve and not through 10-mesh sieve.
作者
焦其树
郝丽霞
吴治丽
代云桃
陈士林
JIAO Qi-shu;HAO Li-xia;WU Zhi-li;DAI;Yun-tao;CHEN Shi-lin(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第1期1-6,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中国中医科学院中药研究所古代经典名方开发研究项目(H2018026)
国家自然科学基金面上项目(81473340)。
关键词
经典名方
煮散
散剂
制备工艺
粉碎粒度
泻白散
当归补血汤
高效液相色谱法(HPLC)
famous classical formulas
decocted powders
powders
preparation technology
crushing size
Xiebaisan
Danggui Buxuetang
high performance liquid chromatography(HPLC)
作者简介
第一作者:焦其树,硕士,从事中药质量分析研究,E-mail:qs_jiao1108@163.com;通信作者:代云桃,博士,研究员,硕士生,导师,从事中药药效物质基础和质量标准研究,E-mail:ytdai@icmm.ac.cn。
