摘要
目的探讨骨髓增生异常综合征(myelodysplastic syndrome,MDS)患者西医WHO分型与中医证型的分布规律。方法回顾性选择2013年1月—2019年12月广东省中医院血液科骨髓增生异常综合征患者102例,收集基本信息资料,进行中医辨病及辨证分型和西医WHO分型,分别统计患者例数,采用卡方检验和对应分析来分析MDS WHO分型与中医证型的相关性。结果中医证型中气阴两虚、毒瘀阻滞证最多见,占68.63%(70/102);WHO分型中MDS-EB-1型最多,占31.37%(37/102),不同中医证型之间WHO分型比较,差异有统计学意义(P <0.05)。对应分析提示MDS患者WHO分型与中医证型之间,差异有统计学意义(P <0.05)。气阴两虚、毒瘀阻滞证与MDS-U型、MDS-5q-型、MDS-SLD型关系最为密切,距离相对值为0.786;脾肾两虚、毒瘀阻滞证与MDS-RS型、MDS-MLD型关系最为密切,距离相对值分别0.315、0.458;邪热炽盛、毒瘀阻滞证与MDS-EB-2型关系最为密切,距离相对值为1.257。结论骨髓增生异常综合征患者中气阴两虚、毒瘀阻滞证和MDS-EB-1型最多见,西医诊断分型与中医证型显著相关,为中西医结合治疗提供一定指导。
Objective To investigate the distribution of WHO and TCM syndromes in patients with myelodysplastic syndrome( MDS).Methods A total of 102 patients with myelodysplastic syndrome in the Department of Hematology of Guangdong Hospital of Traditional Chinese Medicine from January 2013 to December 2019 were selected,and the basic information was collected,and TCM differentiation,syndrome differentiation and Western WHO classification were carried out.The number of patients was counted respectively.The correlation between MDS who classification and TCM syndrome type was analyzed by chi square test and correspondence analysis.Results The most common syndromes were Qi-Yin deficiency and toxin and blood stasis blocking,accounting for 68.63%( 72/102).MDS-EB-1 was the most in WHO classification,accounting for 31.37%( 37/102).There was statistically significant difference between different TCM types( P < 0.05).The corresponding analysis indicated that there was a significant difference between the WHO classification and TCM syndrome type of MDS patients( P < 0.05).The relationship of Qi and Yin deficiency,toxin and blood stasis blocking and MDS-U type,MDS-5 q type and MDS-SLD type was the most closely related.The relative value of distance was 0.786,the relationship of spleen and kidney deficiency,toxin and blood stasis blocking and MDS-RS type and MDS-MLD type was the most close.The relative value of distance was 0.315,0.458.The relationship of pathogenic heat and excessive,toxin and blood stasis blocking and MDS-EB-2 type was most closely related.The relative value of distance was 1.257.Conclusion Deficiency of Qi and Yin,stagnation of toxin and blood stasis and MDS-EB-1 are the most common syndromes in patients with myelodysplastic syndrome.The diagnosis and classification of Western medicine is significantly related to the syndrome types of traditional Chinese medicine,which provides some guidance for the treatment of integrated traditional Chinese and Western medicine.
作者
张文静
王沁
ZHANG Wenjing;WANG Qin(The Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510000,Guangdong,China;Zhuhai Branch of Guangdong Traditional Chinese Medicine Hospital,Zhuliai 519015,Guangdong,China)
出处
《辽宁中医杂志》
CAS
2020年第12期126-129,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省名老中医药专家传承工作室建设项目(0500920170050202)。
关键词
骨髓增生异常综合征
诊断分型
中医证型
分布规律
myelodysplastic syndrome
diagnosis and classification
TCM syndrome type
distribution rule
作者简介
张文静(1994-),女,广东揭西人,医师,硕士研究生,研究方向:中西医结合治疗血液病。
