摘要
Chirality or handedness,i.e.,the non-superimposability of a structure(lacking a plane or center of symmetry)with its mirrorimage,strongly impacts various chemistry/biology areas,and plays an important role,e.g.,in materials chemistry[1].In medicinal chemistry it is critical to evaluate the therapeutic and toxicological properties of all stereoisomers of a drug molecule because diastereoisomers and enantiomers may exhibit distinct biological and pharmacological activities[2].
作者
Subarna Jyoti Kalita
Yi-Yong Huang
Uwe Schneider
Subarna Jyoti Kalita;黄毅勇;Uwe Schneider(Department of Chemistry,School of Chemistry,Chemical Engineering and Life Science,Wuhan University of Technology,Wuhan 430070,China;EaStCHEM School of Chemistry,The University of Edinburgh,Edinburgh EH93FJ,UK)
基金
the financial support from the National Natural Science Foundation of China(21772151)
Natural Science Foundation of Hubei Province(2018CFA084)。
作者简介
Subarna Jyoti Kalita obtained his M.Sc.degree in Applied Chemistry in 2011 from Tezpur University,India.In 2017,he received his Ph.D.degree from Gauhati University,India,under the supervision of Prof.Dibakar Chandra Deka.Currently,he is working as a post-doctoral fellow in Prof.Yi-Yong Huang’s research group at Wuhan University of Technology,China.His research interests focus on the asymmetric synthesis of fluorinated heterocycles using fluorinated building blocks and asymmetric transformations of boron reagents for novel methodology development;Corresponding authors:Yi-Yong Huang obtained his Ph.D.degree with Prof.Qing-Hua Fan in 2007 at the Institute of Chemistry,Chinese Academy of Sciences.After two years of working(2007-2009)as a JSPS postdoctoral researcher at Nagoya Institute of Technology with Prof.Norio Shibata,he joined Shu Kobayashi’s group at the University of Tokyo as a NEDO postdoctoral researcher(20092012).Now he is a‘‘Chutian Scholar”Professor at Wuhan University of Technology,China.His research focuses on homogeneous asymmetric catalysis with boron reagents,allene compounds,and fluorinated building blocks.E-mail addresses:huangyy@whut.edu.cn;Corresponding authors:Uwe Schneider is a Lecturer in the School of Chemistry at the University of Edinburgh.He received his Ph.D.degree with Professors Xavier Pannecoucke and JeanCharles Quirion at IRCOF in Rouen(2003).After postdoctoral studies with Professor Shu Kobayashi at the University of Tokyo,he was appointed as Group Leader(2006)and promoted to Assistant Professor(2007),before taking up his present position(2011).His research interests include:sustainable chemistry;C-H/C-C bond activation;(asymmetric)catalysis;low-oxidation state main group chemistry;base/acid/dual/ambiphilic/FLP catalysis;transition metal-like redox catalysis;bond activation in small molecules.uwe.schneider@ed.ac.uk。
