摘要
目的探讨应用高通量血液透析技术对高龄尿毒症患者钙磷代谢异常的应用研究及预后的影响。方法选取2017年3月至2018年3月该院收治的98例高龄尿毒症患者作为研究对象,随机分为观察组和对照组,每组各49例。对照组患者给予常规血液透析治疗,观察组患者给予高通量血液透析治疗。对两组患者的临床疗效、血清钙磷和全段甲状旁腺激素(PTH)、肾功能指标、预后生活质量、不良反应发生率等进行比较。结果观察组总有效率为89.80%(44/49),高于对照组的73.47%(36/49),差异有统计学意义(P<0.05)。治疗后观察组钙水平高于对照组,磷、PTH水平低于对照组,差异均有统计学意义(P<0.05)。治疗后观察组β2微球蛋白(β2-MG)、血肌酐(SCr)、血清尿素氮(BUN)水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后观察组预后生活质量评分均高于对照组,差异均有统计学意义(P<0.05)。血液透析期间观察组和对照组患者不良反应发生率分别为16.33%(8/49)、10.20%(5/49),差异无统计学意义(P>0.05)。结论应用高通量血液透析技术治疗高龄尿毒症临床疗效明显,能够改善患者的钙磷代谢异常状态及肾功能指标,提高患者的预后生活质量,治疗安全性良好,值得临床推广应用。
Objective To study the effect of high flux hemodialysis on calcium and phosphorus metabolism and prognosis in elderly uremic patients.Methods A total of 98 elderly uremic patients in the hospital from March 2017 to March 2018 were taken as the research objects,and were randomly divided into observation group and control group,49 cases in each group.The patients in the control group were treated with conventional hemodialysis,while those in the observation group were treated with high flux hemodialysis.The clinical effect,serum calcium and phosphorus,parathyroid hormone(PTH),renal function index,prognosis quality of life were compared in two groups.Results The total effective rate of the observation group was 89.80%(44/49),which was higher than 73.47%(36/49)of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum calcium concentration of the observation group was higher than that of the control group,and the serum phosphorus and PTH levels were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels ofβ2-microglobulin(β2-MG),serum creatinine(SCr)and serum urea nitrogen(BUN)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of prognosis quality of life including in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).During hemodialysis,the adverse reactions in the observation group and the control group were 16.33%(8/49)and 10.20%(5/49)and the differences were not statistically significant(P>0.05).Conclusion The clinical effect of high flux hemodialysis in the elderly patients with uremia is significant.It can improve the abnormal state of calcium and phosphorus metabolism,improve the renal function index,improve the prognosis quality of life of the patients,and the treatment safety is good.It is worthy of clinical recommendation.
作者
董娟娟
冯世栋
李亚娟
仲雅
DONG Juanjuan;FENG Shidong;LI Yajuan;ZHONG Ya(Department of Nephrology,Air Force Military University First Affiliated Hospital,Xi′an,Shaanxi 710032,China)
出处
《国际检验医学杂志》
CAS
2020年第21期2611-2614,2619,共5页
International Journal of Laboratory Medicine
基金
陕西省医学科学研究重点课题计划(2016JM3979)。
关键词
尿毒症
高龄患者
高通量血液透析
钙磷代谢
肾功能指标
预后
生活质量
uremia
elderly patients
high flux hemodialysis
calcium and phosphorus metabolism
renal function index
prognosis
quality of life
作者简介
董娟娟,女,主管护师,主要从事血液净化方面的研究;通信作者:仲雅,E-mail:274556999@qq.com。
