摘要
目的探讨中药补肺化痰活血方在慢性阻塞性肺疾病(COPD)合并肺动脉高压患者治疗中的应用价值,观察其对炎症反应、肺功能、外周血内皮祖细胞数量及功能的影响。方法将2016年12月至2018年7月因COPD合并肺动脉高压就诊且中医证型属于肺脾气虚、痰瘀困阻型的96例患者纳入研究并依据随机数字表法分组。对照组48例采用单纯西医治疗,观察组48例则联合中药补肺化痰活血方治疗,治疗2周后比较临床疗效。结果治疗后观察组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、CC-16水平低于对照组,差异具有统计学意义(P<0.05);治疗后观察组用力肺活量(FVC)、第一秒用力呼气量(FEV1)等肺功能指标水平大于对照组,且一氧化氮(NO)、外周血内皮祖细胞(EPCs)、EPCs粘附及迁移能力水平均更高,差异具有统计学意义(P<0.05);治疗后观察组氧分压(PaO2)水平高于对照组,二氧化碳分压(PaCO2)、肺动脉收缩压力(PASP)低于对照组(P<0.05);观察组不良反应总发生率为14.58%(7/48),对照组为18.75%(9/48),差异无统计学意义(P>0.05)。结论对于COPD合并肺动脉高压(肺脾气虚、痰瘀困阻型)患者联合中药补肺化痰活血方治疗,可有效减轻炎症反应,改善肺功能。
Objective To explore the application value of the traditional Chinese medicine Bufei Huatan Huoxue Recipe in the treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary hypertension,and observe its effects on inflammation,lung function,number and function of endothelial progenitor cells in peripheral blood influences.Methods From December 2016 to July 2018,96 patients with COPD and pulmonary hypertension who were treated in our hospital with TCM syndromes of lung and spleen Qi deficiency and phlegm stasis obstruction were enrolled in the study and grouped according to the random number table method.The 48 cases in the control group were treated with Westem medicine alone,and the 48 cases in the observation group were treated with traditional Chinese medicine to invigorate the lungs,dissipate phlegm and promote blood circulation.The clinical ffects were compared after 2 weeks of treatment.Results After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and CC-16 in the observation group were lower than those in the control group,and the diference was ststically signifcant(P<0.05).The levels of lung function indicators such as vital capacity(FVC)and forced expiratory volume in the first second(FEV1)were greater than those of the control group,and the levels of nitric oxide(NO),peripheral blood endothelial progenitor cells(EPCs),EPCs adhesion and migration capabilities were higher,the difference was statitically significant(P<0.05).Afer treatment,,the observation group's oxygen partial pressure(PaO2)level was higher than the control group,carbon dioxide partial pressure(PaCO2)and pulmonary artery systolic pressure(PASP)were lower than the control group(P<0.05);the total incidence of adverse reactions in the observation group was 14.58%(7/48),and the control group was 18.75%(9/48),the difference was not saistically significant(P>0.05).Conclusion For COPD patients with pulmonary hypertension(deficiency of lung and spleen Qi,obtruction of phlegm and blood stais),it is of great signifcance to combine tradional Chinese medicine to nourish the lung,disipate phlgm and promote blood circulation and diuresis.It can effectively reduce inflammation and improve lung function.It is worthy of promotion.
出处
《浙江临床医学》
2020年第10期1458-1460,共3页
Zhejiang Clinical Medical Journal
关键词
慢性阻塞性肺疾病
肺动脉高压
肺功能
血气分析
Chronic obtructive pulmonary disease
Pulmonary hypertension
Lung function
Blood gas analysis
