摘要
目的探讨聚乙二醇化重组人粒细胞刺激因子(pegylated recombinant human granulocyte colony-stimunating factor,PEG-rhG-CSF)预防老年消化道肿瘤患者化疗后中性粒细胞(absolute neutrophil count,ANC)减少的临床效果。方法本研究共纳入47例消化道肿瘤患者,在化疗第一周期的第3天给予6 mg PEG-rhG-CSF皮下注射,若出现ANC减少,则在化疗第二个周期继续给予6 mg PEG-rhG-CSF皮下注射,若未出现ANC减少,则在化疗第二个周期给予3 mg PEG-rhG-CSF皮下注射。结果化疗第一周期、化疗第二周期3 mg PEG-rhG-CSF、化疗第二周期6 mg PEG-rhG-CSF后ANC减少症的发生率分别为19.1%、31.6%、55.6%(P<0.05);三者之间的ANC减少症持续时间比较差异无统计学意义(P>0.05)。化疗第一周期、化疗第二周期3 mg PEG-rhG-CSF、化疗第二周期6 mg PEG-rhG-CSF的FN发生率分别为4.3%、7.9%、11.1%,差异无统计学意义(P>0.05)。研究期间有2例出现骨痛、1例出现乏力、1例出现肌肉疼痛,不良反应总发生率为8.5%。结论化疗期间使用PEG-rhG-CSF可有效预防老年消化道肿瘤患者化疗后中性粒细胞减少的发生,且安全性较好。
Objective To explore the clinical effect of pegylated recombinant human granulocyte stimulat⁃ing factor(PEG⁃rhG⁃CSF)in the prevention of neutropenia after chemotherapy in elderly patients with gastrointesti⁃nal cancer.Methods A total of 47 patients with digestive tract tumors were included in this study.They were given a subcutaneous injection of 6 mg PEG⁃rhG⁃CSF on the third day of the first cycle of chemotherapy.If ANC decreased,they were given subcutaneous injection of 6 mg PEG⁃rhG⁃CSF on the second cycle of chemotherapy.If ANC did not decrease,they were given a subcutaneous injection of 3 mg PEG⁃rhG⁃CSF on the second cycle of che⁃motherapy.Results In the first cycle of chemotherapy,the second cycles of chemotherapy with 3 mg PEG⁃rhG⁃CSF and the second cycles of chemotherapy with 6 mg PEG⁃rhG⁃CSF,the incidence of FN was 19.1%,31.6%and 55.6%(P<0.05).There was no significant difference in duration of ANC reduction in the three groups(P>0.05).In the first cycle of chemotherapy,the second cycles of chemotherapy with 3 mg PEG⁃rhG⁃CSF and the second cycles of chemotherapy with 6 mg PEG⁃rhG⁃CSF,the incidence of FN was 4.3%,7.9%and 11.1%,which was no significant difference(P>0.05).During the study period,there were 2 cases with bone pain,1 case with asthenia and 1 case with muscle pain.The total incidence of adverse reactions was 8.5%.Conclusion PEG⁃rhG⁃CSF can effectively prevent neutropenia in elderly patients with gastrointestinal cancer,and it has high safety.
作者
周建红
陈海辉
张日光
黄慧娴
ZHOU Jianhong;CHEN Haihui;ZHANG Riguang;HUANG Huixian(The Fourth Affiliated Hospital of Guangxi Medical University(Liuzhou workers Hospital),Liuzhou 545005,China)
出处
《实用医学杂志》
CAS
北大核心
2020年第20期2825-2829,共5页
The Journal of Practical Medicine
基金
希思科-齐鲁肿瘤研究基金项目(编号:Y-Q201801-047)。
关键词
聚乙二醇化重组人粒细胞刺激因子
老年
消化道肿瘤
化疗
中性粒细胞减少
pegylated recombinant human granulocyte stimulating factor
elderly
gastrointestinal cancer
chemotherapy
absolute neutrophil count
作者简介
通信作者:黄慧娴,E⁃mail:HHX456669@163.com。
