摘要
目的:分析联合检测γ-干扰素释放试验(T-SPOT.TB)、结核菌素试验(PPD)、血清结核抗体检测(TB-Ab)在活动性肺结核(APTB)中的临床意义。方法:选取60例疑似APTB患者为研究对象,均行T-SPOT.TB、PPD及TB-Ab检测,以最终确诊结果为准,分析三种方法单独及联合检测的临床意义。结果:60例患者,确诊为APTB 26例,34例为非APTB;T-SPOT.TB结果显示,APTB患者结核特异细胞斑点数高于非APTB患者(P<0.05);T-SPOT.TB诊断APTB的灵敏度、特异度、准确度分别为88.46%、91.18%和90.00%,PPD诊断APTB的灵敏度、特异度和准确度分别为57.69%、67.65%和63.33%,TB-Ab诊断APTB的灵敏度、特异度和准确度分别为61.54%、67.65%、65.00%,T-SPOT.TB、PPD及TB-Ab联合检测诊断效能最高,其诊断灵敏度96.15%、特异度100.00%、准确度98.33%均高于三者单项或两项(T-SPOT.TB+PPD、T-SPOT.TB+TB-Ab、PPD+TB-Ab)联合检测(P<0.05)。结论:联合检测T-SPOT.TB、PPD及TB-Ab可提高对APTB的诊断效能,值得在临床推广实践。
Objective:To analyze the clinical significance of combined detection of interferon-gamma release assay(T-SPOT.TB),Purified Protein Derivative of tuberculin(PPD)and serum tuberculosis antibody(TB-Ab)in active pulmonary tuberculosis(APTB).Methods:A total of 60 suspected APTB patients were enrolled in the study.T-SPOT.TB,PPD and TB-Ab were performed on them.Taking the final diagnosis results as the standard,the clinical significance of the three methods and their combination detection was analyzed.Results:In the 60 patients,there were 26 cases with APTB,34 cases with non-APTB.T-SPOT.TB results showed that number of tuberculosis-specific cells in APTB patients was higher than that in non-APTB patients(P<0.05).The sensitivity,specificity and accuracy of T-SPOT.TB for the diagnosis of APTB were 88.46%,91.18%,and 90.00%,respectively.The above 3 indexes of PPD were 57.69%,67.65%and 63.33%,respectively.The above 3 indexes of TB-Ab were 61.54%,67.65%and 65.00%,respectively.The diagnostic efficiency of T-SPOT.TB,PPD and TB-Ab combined detection was the highest.And the diagnostic sensitivity,specificity and accuracy were 96.15%,100.00 and 98.33%,respectively,which were higher than those of single or two of the three(T-SPOT.TB+PPD,T-SPOT.TB+TB-Ab,PPD+TB-Ab,P<0.05).Conclusion:Combined detection of T-SPOT.TB,PPD and TB-Ab can improve the diagnostic efficiency for APTB,which is worthy of clinical application.
作者
刘裔
韩红洋
LIU Yi;HAN Hong-yang(Department of Tuberculosis,Nanjing Second Hospital,Nanjing 210000,Jiangsu,China)
出处
《川北医学院学报》
CAS
2020年第5期907-910,共4页
Journal of North Sichuan Medical College
作者简介
刘裔(1985-),男,住院医师。E-mail:3892721@qq.com;通讯作者:韩红洋。E-mail:3892721@qq.com。
