摘要
目的肺结核主要是受结核分枝杆菌感染后引起肺部感染的一种疾病,严重影响人们生活质量,采取及时有效的诊断和治疗方式对不典型肺结核预后尤为重要。本研究探讨结核感染T细胞斑点试验(T-cell spot test for tuberculosis infection,TSPOT.TB)诊断不典型肺结核的效果。方法选择泰安市肿瘤防治院2016-01-30-2018-01-30收治的117例疑似肺结核患者作为研究对象,根据诊断标准,确诊不典型肺结核患者78例,非肺结核患者39例。分别采用结核菌素皮试(tuberculin skin test,TST)和TSPOT.TB进行检测。结果不典型肺结核组TST检出阳性率为50.00%,高于非肺结核组的28.21%,差异有统计学意义,χ~2=5.047,P=0.025;不典型肺结核组TSPOT.TB检出阳性率为97.44%,高于非肺结核组的5.13%,差异有统计学意义,χ~2=99.692,P<0.001;不典型肺结核患者采用TSPOT.TB检测灵敏度为97.44%,高于TST的50.00%,差异有统计学意义,χ~2=45.29,P<0.01;不典型肺结核患者采用TSPOT.TB检测特异度为94.87%,高于TST的71.79%,χ~2=7.48,P<0.01。结论TSPOT.TB诊断不典型肺结核的敏感度和特异度均高于TST,对于不典型肺结核患者具有良好的诊断价值。
OBJECTIVE Pulmonary tuberculosis(TB)is mainly a disease caused by pulmonary infection caused by mycobacterium tuberculosis,which seriously affects people’s quality of life.This study is to investigate the effectiveness of the t-cell spot test for tuberculosis infection(TSPOT.TB)in the diagnosis of atypical tuberculosis.METHODS A total of117 suspected pulmonary tuberculosis patients admitted to Taian Tumour Prevention and Treatment Hospital from January 30,2016 to January 30,2018 were selected as the research objects.According to the diagnostic criteria,78 patients with atypical pulmonary tuberculosis and 39 patients without pulmonary tuberculosis were diagnosed.Tuberculin skin test(TST)and TSPOT.TB were used,respectively.RESULTS The positive rate of tspot was 50.00%in atypical tuberculosis group,higher than 28.21%in non tuberculosis group,the difference was statistically significant,χ~2=5.047,P=0.025;the positive rate of TSPOT.TB in atypical tuberculosis group was 97.44%,higher than 5.13%in non tuberculosis group,the difference was statistically significant,χ~2=99.692,P<0.001;the sensitivity of TSPOT.TB in atypical tuberculosis group was 97.44%,higher than 5.00%in TST,the difference was statistically significant(χ~2=45.29,P<0.01);the specificity of TSPOT.TB in atypical tuberculosis patients was 94.87%,higher than 71.79%in TST,the difference was statistically significant,χ~2=7.48,P<0.01.CONCLUSIONS The sensitivity and specificity of TSPOT.TB in the diagnosis of atypical tuberculosis are higher than that of TST.It has a good diagnostic value for atypical tuberculosis patients.
作者
孙霞
毛庆珺
SUN Xia;MAO Qing-jun(Clinical Laboratory,Taian Tumour Prevention and Treatment Hospital,Taian27100,P.R.China)
出处
《社区医学杂志》
2020年第4期286-288,共3页
Journal Of Community Medicine
关键词
结核感染T细胞斑点试验
不典型肺结核
敏感性
特异性
T-cell spot test for tuberculosis infection
atypical pulmonary tuberculosis
sensitivity
specificity
作者简介
通信作者:孙霞,女,山东宁阳人,主管技师,主要从事医学检验的临床研究工作。E-mail:13583835718@163.com
