摘要
目的探究痰热清注射液联合利巴韦林颗粒治疗小儿病毒性肺炎的临床疗效。方法选取2018年10月—2019年10月在洛阳新区人民医院治疗的110例病毒性肺炎患儿,将所有患儿按照随机数字表法分为对照组和治疗组,每组各55例。对照组患儿口服利巴韦林颗粒,0.01 g/(kg·次),3次/d,治疗组在对照组治疗基础上静脉滴注痰热清注射液,按照0.5 mL/kg溶解于5%葡萄糖中,1次/d。两组患儿共治疗2周。观察两组的患儿临床疗效,比较两组的临床症状消失时间、血清炎症因子。结果治疗后,对照组总有效率为85.45%,治疗组总有效率为98.18%,差异有统计学意义(P<0.05)。治疗后,治疗组体温恢复时间、咳嗽消失时间、肺啰音消失时间、住院时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平均显著下降(P<0.05);治疗后治疗组患儿hs-CRP、TNF-α、IL-6、IL-8水平明显低于对照组,差异有统计学意义(P<0.05)。结论痰热清注射液联合利巴韦林颗粒治疗小儿病毒性肺炎具有较好的临床疗效,能够改善临床症状,降低血清炎性指标水平,安全性好。
Objective To investigate the clinical efficacy of Tanreqing Injection combined with Ribavirin Granules in treatment of viral pneumonia in children.Methods Children(110 cases)with viral pneumonia in New Area People’s Hospital of Luoyang from October 2018 to October 2019 were randomly divided into control and treatment groups,and each group had 55 cases.Children in the control group were po administered with Ribavirin Granules,0.01 g/(kg·time),three times daily.Children in the treatment group were iv administered with Tanreqing Injection on the basis of the control group,0.5 mL/kg added into 5%glucose solution,once daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical efficacies were evaluated,and clinical symptoms disappear time and serum inflammatory factors in two groups were compared.Results After treatment,the total effective rate of the control group and treatment group were 85.45%and 98.18%,and the difference was statistically significant(P<0.05).After treatment,the body temperature recovery time,cough disappear time,lung rales disappear time and hospitalization time in the treatment group were significantly shorter than those in the control group,and there was difference between two groups(P<0.05).After treatment,the levels of hs-CRP,TNF-α,IL-6,and IL-8 in two groups were significantly decreased(P<0.05).And the levels of hs-CRP,TNF-α,IL-6,and IL-8 in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Tanreqing Injection combined with Ribavirin Granules has clinical curative effect in treatment of viral pneumonia in children,can improve the clinical symptoms,reduce the level of serum inflammatory indicators,with good safety.
作者
乔喜娟
贺孝良
QIAO Xi-juan;HE Xiao-liang(Department of Pediatrics,New Area People’s Hospital of Luoyang,Luoyang 471023,China;Department of Pediatrics,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《现代药物与临床》
CAS
2020年第8期1655-1658,共4页
Drugs & Clinic
关键词
痰热清注射液
利巴韦林颗粒
小儿病毒性肺炎
临床症状消失时间
炎症因子
Tanreqing Injection
Ribavirin Granules
viral pneumonia in children
clinical symptom disappear time
inflammatory factor
作者简介
乔喜娟(1980—),女,河南洛阳人,副主任医师,本科,研究方向为儿内科呼吸。E-mail:surgery15@163.com。
