摘要
目的:分析和比较新活素(Lrh-BNP)与硝普钠(SNP)治疗急性失代偿心力衰竭(ADHF)的临床效果及对患者循环指标心肌肌钙蛋白I(cTnI)、N末端B型利钠肽原(NT-proBNP)、超敏C反应蛋白(hs-CRP)水平的影响。方法:选取本院2015年5月至2018年5月收治的98例ADHF患者,采取简单随机数字表法均分为两组。Lrh-BNP组加用新活素治疗,SNP组予以硝普钠治疗。记录比较两组临床疗效,治疗前后心功能指标及循环cTnI、NT-proBNP、hs-CRP水平的变化及不良反应的发生情况。结果:治疗7d后,Lrh-BNP组总有效率较SNP组明显升高(P<0.05)。与治疗前对比,两组治疗7d后LVEF值均显著上升(P<0.01),LVEDD、LVESD值血浆cTnI、NT-proBNP、hs-CRP水平均明显降低(P<0.05),且Lrh-BNP组LVEF值显著高于SNP组(P<0.05),LVEDD、LVESD值血浆cTnI、NT-proBNP、hs-CRP水平均明显低于SNP组(P<0.01)。Lrh-BNP组不良反应率与SNP组相比差异无统计学意义(P>0.05)。结论:与硝普钠相比,应用新活素治疗ADHF显著提高其临床疗效,改善患者心功能,可能与其显著降低血浆cTnI、NT-proBNP、hs-CRP水平有关,且二者安全性相当。
Objective:To analyze and compare the clinical effect on acute decompensated heart failure(ADHF)between lyophilized recombinant human brain natriuretic peptide(Lrh-BNP)and sodium nitroprusside(SNP)and influence on the plasma cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP)and hypersensitivity C reactive protein(hs-CRP)levels.Methods:98 patients with ADHF admitted to our hospital from May 2015 to May 2018 were selected and evenly divided into two groups with simple random number table method.Lrh-BNP group was treated with Lrh-BNP while SNP group was treated with SNP.The clinical effect,changes of heart function indexes and plasma cTnI,NT-proBNP and hs-CRP levels before and after treatment as well as the incidence of adverse reactions were compared between the two groups.Results:The overall effective rate of Lrh-BNP group after treatment for 7 days was evidently higher than that of SNP group(P<0.05).The LVEF values of both groups 7d after treatment were significantly increased as compared with those before treatment(P<0.01),and the LVEDD,LVESD values,plasma cTnI,NT-proBNP and hs-CRP levels were significantly decreased as compared with those before treatment(P<0.05).The LVEF value of Lrh-BNP group was higher than that of the SNP group(P<0.05),while the LVEDD,LVESD values,plasma cTnI,NT-proBNP and hs-CRP levels of Lrh-BNP group were obviously lower than those of the control group(P<0.01).No difference was found between the two groups in the incidence of adverse reactions(P>0.05).Conclusion:Compared with SNP,Lrh-BNP could obviously enhance the clinical efficacy in the treatment of ADHF,improve the cardiac function,which might be related to decrease the plasma levels of cTnI,NT-proBNP and hs-CRP.
作者
张诗锐
朱理
袁玉玲
田国红
李华波
ZHANG Shirui;ZHU Li;YUAN Yuling(The Affiliated Minda Hospital of Hubei University of Nationalities, Hubei Enshi 445000, China)
出处
《河北医学》
CAS
2020年第9期1429-1434,共6页
Hebei Medicine
基金
湖北省自然科学基金项目,(编号:20130324)。
关键词
急性失代偿心力衰竭
新活素
硝普钠
心肌肌钙蛋白I
N末端B型利钠肽原
Acute decompensated heart failure
Lyophilized recombinant human brain natriuretic peptide
Sodium nitroprusside
Cardiac troponin
N-terminal pro-brain natriuretic peptide
