摘要
【目的】探讨贲门癌患者的癌胚抗原(CEA)、糖链抗原50(CA50)和糖链抗原125(CA125)表达情况及临床意义。【方法】贲门癌患者80例为观察组,选取同期在本院体检的健康成年人作为对照。观察两组患者血清CA125、CA50、CEA水平,比较不同临床病理特征贲门癌患者CA125、CA50、CEA水平的差异。【结果】观察组患者的血清CA125、CA50、CEA水平分别为(52.35±5.17)U/mL、(7.34±1.32)U/mL、(3.46±0.92)ng/mL,高于对照组的(25.46±2.09)U/mL、(5.86±1.01)U/mL、(1.85±0.84)ng/mL,且差异有显著性(均P<0.01);临床分期为Ⅲ期、组织学分级为中、低分化、有淋巴结转移的贲门癌患者的CA125、CA50、CEA水平较高,不同性别的贲门癌患者CA125、CA50、CEA水平无明显差别。回归分析结果显示,淋巴结转移是影响贲门癌患者CA125、CA50、CEA水平的相关因素。【结论】贲门癌患者的CA125、CA50、CEA表达水平较高,且受淋巴结转移情况的影响。
【Objective】To investigate the expression and clinical significance of carcinoembryonic antigen(CEA),carbohydrate antigen(CA125 and CA50)in patients with cardiac cancer.【Methods】A total of 80 patients with cardiac cancer were selected as the observation group.At the same time period,80 healthy volunteers were enrolled as the control group.The serum levels of CA125,CA50 and CEA were measured and compared in the two groups.The differences of CA125,CA50 and CEA levels in patients with different staging of cardiac cancer were compared as well.【Results】Serum CA125,CA50 and CEA levels in the observation group were 52.35±5.17 U/mL,7.34±1.32 U/mL,3.46±0.92 ng/mL,respectively,which were higher than those of the control group(25.46±2.09 U/mL,5.86.±1.01 U/mL,1.85±0.84 ng/mL,respectively).The differences were statistically significant(P<0.01).The levels of CA125,CA50,and CEA levels were higher in cardiac cancer patients with clinical stageⅢ,medium and moderate and poorly differentiated histological grade,and with lymph node metastasis.There were no significant differences in CA125,CA50,and CEA levels between patients with different genders.Regression analysis of CEA level as a dependent variable showed that lymph node metastasis was a factor affecting CA125,CA50,and CEA levels in patients with cardiac cancer.【Conclusion】The expression levels of CA125,CA50 and CEA in patients with cardiac cancer are higher and are affected by lymph node metastasis.
作者
王祥军
田川
张建设
WANG Xiang-jun;TIAN Chuan;ZHANG Jian-she(Chest Tumor Surgery Department,Xinyi Hospital of Traditional Chinese Medicine,Jiangsu Province,221400)
出处
《医学临床研究》
CAS
2020年第8期1178-1180,共3页
Journal of Clinical Research
作者简介
通讯作者:王祥军,E-mail:chengbao20863@163.com。
