摘要
目的探讨缺血性脑小血管病(ICSVD)致血管性认知功能障碍(VCI)的相关危险因素,为临床诊治提供参考。方法选取ICSVD及ICSVD合并VCI患者80例,其中ICSVD组32例,ICSVD合并VCI组48例,对照组30例(符合纳入标准的门诊体检人员)。采集所有对象的既往史、个人史、家族史,另外采集收缩压(SBP)及舒张压(DBP)、头颅MRI、颈动脉内膜-中膜厚度(IMT)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、同型半胱氨酸(Hcy)等资料。结果3组受教育年限、不良习惯及合并疾病比较差异有统计学意义(P<0.05),但ICSVD组与ICSVD合并VCI组两两比较差异无统计学意义(P>0.05);3组彩超IMT、血压及血检数据比较差异有统计学意义(P<0.05),ICSVD组与ICSVD合并VCI组两两比较差异无统计学意义(P>0.05),但ICSVD组与ICSVD合并VCI组IMT和Hcy比较差异有统计学意义(P<0.05)。结论受教育年限短、吸烟、饮酒、高IMT、高血压、高血糖、高血脂、高Hcy是临床引起ICSVD及VCI重要危险因素;IMT及血清Hcy数值越高,颈动脉管径越细或狭窄,动脉粥样硬化越严重,可能是ICSVD引起VCI重要危险因素。
Objective To investigate the correlation between vascular cognitive impairment(VCI)caused by ischemic small vessel disease(ICSVD)and gender,education,hyperglycemia,hypertension,hyperlipidemia,homocysteine,smoking and alcohol consumption.Methods Eighty patients with ICSVD and ICSVD combined VCI were admitted.There were 32 cases in ICSVD group,48 cases in ICSVD combined VCI group and 30 cases in control group(the physical examinated staffs in out-patient according to the inclusion criteria).The information or data were collected including past history,personal history,family history,blood pressure(SBP and DBP),cranial MRI,IMT,FBG,TC,TG,LDL,Hcy.Results The differences among the three groups in years of education,bad habits and complications were statistically significant(P<0.05),however,there was not statistically significant difference between the ICSVD group and ICSVD combined VCI group(P>0.05).The difference of IMT,blood pressure and blood test data among the three groups was statistically significant(P<0.05);there was not statistically significant difference between the ICSVD group and ICSVD combined VCI group(P>0.05),however,there were statistically significant differences about IMT and Hcy indexes in ICSVD group and ICSVD combined VCI group(P<0.05).Conclusion They are important risk factors of inducing clinical ICSVD and VCI including short years of education,smoking,drinking alchohol,high IMT,hypertension,hyperglycaemia,hyperlipaemia and high Hcy.The higher the IMT and serum Hcy data,the smaller or narrower the carotid artery diameter,the more severe the atherosclerosis,which may be an important risk factor for the VCI caused by ICSVD.
作者
张德绸
葛建华
叶丽莎
冯启峰
ZHANG Dechou;GE Jianhua;YE Lisha;FENG Qifeng(Affiliated TCM Hospital Southwest Medical University,Luzhou 646000,China;Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处
《中国实用神经疾病杂志》
2020年第17期1520-1524,共5页
Chinese Journal of Practical Nervous Diseases
基金
四川省教育厅课题(编号:16ZB0203)。
关键词
缺血性脑小血管病
血管性认知功能障碍
血管性痴呆
危险因素
血脂
Ischemic small cerebral vessel disease(ICSVD)
Vascular cognitive impairment(VCI)
Vascular dementia
Risk factors
Blood lipids
作者简介
张德绸,Email:zdchou2328@126.com;通信作者:葛建华,Email:orthodrgjh@126.com。
