摘要
霉酚酸(MPA)类药物是器官移植受者常用的免疫抑制剂,具有良好的免疫抑制效果,但用药不足或过量均不利于受者预后,需要准确控制给药剂量。MPA的代谢具有较大个体差异,因此这类药物的代谢规律、监测手段在临床上具有重要意义。本文综述了近5年MPA类药物在器官移植受者中代谢规律的研究进展,归纳了药物代谢规律和监测手段研究的主要结果和方向,对器官移植中MPA类药物代谢的研究进行了简要的回顾和展望。
Mycophenolic acid(MPA)drugs are common immunosuppressant for organ transplant recipients,which possesses high immunosuppressive effect.However,insufficient or excessive dosage of MPA is not conducive to clinical prognosis of the recipients.Hence,it is necessary to accurately control the dosage of MPA.The metabolism of MPA significantly differs among individuals.The metabolic pattern and monitoring method of these drugs are of important significance in clinic.In this article,the research progresses on the metabolism of MPA drugs in organ transplant recipients in recent five years were reviewed,the main results and direction of drug metabolism and monitoring methods were summarized,and the researches on the metabolism of MPA drugs in organ transplantation were briefly reviewed and prospected.
作者
曹懿睿
贾亦臣
Cao Yirui;Jia Yichen(Department of Urology,Zhongshan Hospital Affiliated to Fudan University,Shanghai Key Laboratory of Organ Transplantation,Shanghai 200320,China)
出处
《器官移植》
CAS
CSCD
北大核心
2020年第5期635-645,共11页
Organ Transplantation
基金
国家自然科学基金(81770747)。
关键词
霉酚酸
器官移植
药代动力学
免疫抑制剂
钙调磷酸酶抑制剂
吗替麦考酚酯
曲线下面积
Mycophenolic acid
Organ transplantation
Pharmacokinetics
Immunosuppressant
Calcineurin inhibitor
Mycophenolate mofetil
Area under curve
作者简介
曹懿睿,男,1996年生,硕士,研究方向为器官移植,Email:13817049614@163.com;通信作者:贾亦臣,男,1983年生,博士,主治医师,研究方向为器官移植,Email:jia.yichen@zs-hospital.sh.cn。
