摘要
目的探讨膳食N-羟乙酰神经氨酸(Neu5Gc)摄入水平与机体慢性炎症状态的关系。方法所有食物样品均于2019年9月购自厦门某超市,包括谷物、肉类、家禽、海鲜、鸡蛋、豆类、乳制品、蔬菜和水果等,共计102种306份,采用液相色谱-质谱联用法测定食物Neu5Gc含量。采用简单随机抽样抽取厦门大学健康入学新生500名,采用食物频率调查表调查研究对象过去1年内食物摄入情况,采用连续3 d 24 h回顾法校正食用量,计算对象的Neu5Gc摄入量。检测血清抗-Neu5Gc抗体、C反应蛋白(CRP)和白细胞介素-6(IL-6)水平。采用Spearman相关分析探索Neu5Gc摄入量与抗-Neu5Gc抗体以及CRP和IL-6等指标的相关性。结果Neu5Gc主要存在于红肉和液态乳制品,在牛、羊和猪肉中的含量分别为(30.32±2.84)、(20.39±4.73)和(5.58±1.04)mg/kg,在液态牛奶和酸奶中的含量分别为(10.87±1.54)和(6.91±0.24)mg/L。Neu5Gc摄入量的M(P25,P75)为4.62(2.20,8.60)mg/d,其中男生为6.60(2.83,10.20)mg/d,高于女生[3.84(1.84,6.35)mg/d](P<0.001)。血清抗-Neu5Gc、CRP和IL-6水平的M(P25,P75)分别为3.07(2.17,4.14)μg/ml,0.37(0.22,0.87)mg/ml和61.82(12.23,315.30)pg/ml。Neu5Gc摄入水平与血清抗-Neu5Gc抗体、CRP和IL-6水平均呈正相关,rs值分别为0.222、0.102和0.126,P值均<0.05。结论膳食Neu5Gc摄入主要来自红肉和液态乳制品,其摄入水平与机体慢性炎症状态呈正相关。
Objective To explore the correlation between dietary N-glycolylneuraminic acid(Neu5Gc)intake and chronic inflammation state of body.Methods A total of 306 samples of 102 types of food were purchased from a supermarket in Xiamen in September 2019,including grains,meat,poultry,seafood,eggs,beans,dairy products,vegetables and fruits.The content of Neu5Gc in food was determined by liquid chromatography-mass spectrometry.A total of 500 healthy freshmen from Xiamen University were selected by using a simple random sampling method.The food frequency questionnaire was used to investigate the food intake in the past year.The food intake was corrected by 3 consecutive 24-hour recalls,and the amount of Neu5Gc intake was calculated.The concentration of anti-Neu5Gc antibody,C-reactive protein(CRP)and interleukin-6(IL-6)in serum was detected.Spearman correlation analysis was used to explore the correlation between Neu5Gc intake and anti-Neu5Gc antibody,CRP and IL-6 levels.Results Neu5Gc was mainly found in red meat and liquid dairy products.The contents of Neu5Gc in beef,lamb and pork were(30.32±2.84),(20.39±4.73)and(5.58±1.04)mg/kg,respectively,and in liquid milk and yogurt were(10.87±1.54)and(6.91±0.24)mg/L,respectively.The M(P25,P75)intake of Neu5Gc for all participants was 4.62(2.20,8.60)mg/d.The M(P25,P75)intake of Neu5Gc for males about 6.60(2.83,10.20)was higher than that for females about[3.84(1.84,6.35)mg/d](P<0.001).The M(P25,P75)of serum anti-Neu5Gc,CRP and IL-6 levels were 3.07(2.17,4.14)μg/ml,0.37(0.22,0.87)mg/ml and 61.82(12.23,315.30)pg/ml,respectively.Spearman correlation analysis showed that the intake level of Neu5Gc was positively correlated with serum anti-Neu5Gc antibody,CRP and IL-6 levels,with rs values about 0.222,0.102 and 0.126,respectively(all P values<0.05).Conclusion Dietary Neu5Gc intake is mainly from red meat and liquid dairy products,and its intake level is positively correlated with chronic inflammatory state of body.
作者
庄滢滢
郑晗盈
兰慧
李红卫
Zhuang Yingying;Zheng Hanying;Lan Hui;Li Hongwei(School of Public Health,Xiamen University,Xiamen 361101,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2020年第6期668-672,共5页
Chinese Journal of Preventive Medicine
基金
达能膳食营养研究与宣教基金项目(DIC2012-12)。
关键词
膳食
唾液酸类
炎症
横断面研究
Diet
Sialic acids
Inflammation
Cross-sectional studies
作者简介
通信作者:李红卫,Email:rocque@xmu.edu.cn。
