摘要
目的了解2012-2018年开封市手足口病的病原型别及分布特征。方法2012年1月至2018年12月逐月采集开封市儿童医院临床诊断为疑似手足口病病例的粪便标本2437例,应用实时荧光PCR法对肠道病毒71型(EV71)、柯萨奇病毒A组16型(CV-A16)和其他肠道病毒(PE)核酸进行检测。结果2437例标本中,检出肠道病毒阳性1883例,阳性检出率为92.44%,其中EV71、CV-A16的阳性率分别为48.71%、12.27%,PE阳性率为32.25%。EV71的占比有逐年降低的趋势,PE的占比有逐年增加的趋势。送检的临床诊断病例中3岁内的婴幼儿占比高达88.31%,3岁以下和3岁以上儿童病原谱差异及性别间病原谱差异均无统计学意义。结论2012-2018年引起手足口病的主要病原是EV71,但PE的构成比呈上升趋势,需要持续关注病原谱变化。3岁内婴幼儿是手足口病主要感染人群,应重点关注。
Objective To analyze etiology of hand-foot-mouth disease(HFMD)in Kaifeng from 2012 to 2018.Methods 2437 stools specimens were collected from suspected patients of HFMD from Kaifeng Children's Hospital during 2012 and 2018.Real-time PCR was used to detect enterovirus 71(EV71),Coxsackie virus A16(CV-Al 6),pan-enterovirus(PE).Results Among the 2437 samples,1883 were positive for enterovirus,with a positive rate of 92.44%,including EV71(48.71%)and CVA16(12.27%)and PE(32.25%).The proportion of EV71 has a decreasing trend,and the proportion of PE increased.The proportion of patients younger than 3 years old was highest,accounted for 88.31%.There was no significant difference in the positive rate between different ages.Conclusions The major etiological agent was EV71 during 2012-2016,but the proportion of PE was increasing.The children less than three old years were main infected population of HFMD,and should be paid more attention to them.
作者
胡淮洁
巩飚
王雪
HU Huaijie;GONG Biao;WANG Xue(Kaifeng Center for Diseases Control and Prevention,Kaifeng,Henan475000,China)
出处
《河南预防医学杂志》
2020年第7期536-538,共3页
Henan Journal of Preventive Medicine
作者简介
通讯作者:胡淮洁,主管技师,本科,研究方向:病原微生物检测,E-mail:huhuaijie@126.com。
