摘要
目的观察沙丁胺醇雾化吸入联合孟鲁司特治疗小儿哮喘急性发作的临床疗效及对患儿肺功能、T淋巴细胞亚群的影响。方法选取医院2016年6月至2018年10月收治的哮喘急性发作患儿126例,按随机数字表法分为治疗组和对照组,各63例。两组患儿均予吸氧、抗感染及解除痉挛等常规治疗,并予孟鲁司特钠片口服,治疗组患儿加用硫酸沙丁胺醇雾化吸入治疗,均治疗1周。结果治疗组总有效率为95.24%,明显高于对照组的84.13%(P<0.05);治疗后,两组患儿的呼气峰流速(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和FEV1/FVC均明显升高,且治疗组均明显高于对照组(P<0.05);治疗组各临床症状缓解时间均明显短于对照组,日间和夜间的哮喘症状评分均明显低于对照组(P<0.05);两组患儿CD4+和CD4+/CD8+水平均明显下降,治疗组明显低于对照组,CD8+水平明显升高,治疗组均明显高于对照组(P<0.05);两组患儿治疗期间均未见严重不良反应,血常规、肝肾功能、心电图等均未见明显异常。结论沙丁胺醇雾化吸入联合孟鲁司特治疗哮喘急性发作患儿,可明显改善肺功能和免疫功能。
Objective To observe the clinical efficacy of salbutamol aerosol inhalation combined with montelukast for acute episode of asthma in children and its influence on pulmonary function and T lymphocyte subsets.Methods A total of 126 children with acute episode asthma were selected and divided into the treatment group and control group according to random number table method,63 cases in each group.Both groups were given conventional treatments such as oxygen inhalation,anti-infection and spasm relief,and were given montelukast orally;the treatment group was added with ventolin aerosol inhalation on this basis.All patients were treated for 1 week.Results The total effective rate of the treatment group was 95.24%,which was significantly higher than 84.13%of the control group(P<0.05).After treatment,the levels of peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume(FEV1)and FEV1/FVC%in the two groups were significantly increased,and the improvements in the treatment group were better than those of the control group(P<0.05).The relief time of clinical symptoms in the treatment group was significantly shorter than that in the control group,the asthma symptom scores of day and night in the treatment group were significantly lower than those in the control group(P<0.05).The levels of CD4+and CD4+/CD8+in the two groups decreased significantly,and the treatment group was significantly lower than the control group;the levels of CD8+in the two groups were significantly increased,and the treatment group was significantly higher than the control group(P<0.05).There were no serious adverse reactions during the treatment,and no obvious abnormalities in blood routine,liver and kidney function,electrocardiogram and so on.Conclusion Salbutamol aerosol inhalation combined with montelukast for acute episode of asthma in children can significantly improve the pulmonary function and immune function of the patients.
作者
张京
李静
周晓静
ZHANG Jing;LI Jing;ZHOU Xiaojing(Handan City Maternal and Child Health Care Center,Handan,Hebei,China 056000)
出处
《中国药业》
CAS
2020年第12期81-83,共3页
China Pharmaceuticals
基金
河北省医学科学研究重点课题[182777180]。
关键词
小儿
哮喘急性发作
沙丁胺醇
孟鲁司特
雾化吸入
肺功能
T淋巴细胞亚群
临床疗效
children
acute episode asthma
salbutamol
montelukast
aerosol inhalation
pulmonary function
T lymphocyte subsets
clinical effficacy
作者简介
第一作者:张京,女,大学本科,主治医师,研究方向为儿科学,(电子信箱)251089837@qq.com;通信作者:李静,大学本科,副主任医师,研究方向为儿科学,(电子信箱)zhaohua9303@sina.com。
