摘要
目的 探讨沙丁胺醇联合布地奈德雾化吸入对支气管哮喘急性发作患者的疗效及其对血清炎性因子的影响。方法 选取2017年1月至2018年12月浙江新安国际医院收治的支气管哮喘急性发作患者78例,按照随机数字表法分为联合组和对照组各39例。对照组采用常规治疗,联合组在对照组基础上采用沙丁胺醇联合布地奈德雾化吸入治疗。两组疗程均为2周。比较两组临床疗效,治疗前后肺功能指标[肺活量(VC)、第一秒用力呼气容积(FEV1)、呼气峰值流速(PEF)]的变化情况,并测定两组患者治疗前后血清高迁移率族蛋白1(HMGB1)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)变化情况。结果 联合组总有效率为87.18%(34/39),高于对照组的68.57%(24/39),差异有统计学意义(χ2=5.791,P<0.05)。治疗前,两组VC、FEV1、PEF差异均无统计学意义(t=0.588、0.892、0.371,均P>0.05);治疗后,两组VC、FEV1、PEF均升高(联合组:t=16.045、7.193、6.667,对照组:t=7.834、8.354、4.262,均P<0.05);治疗后,联合组VC、FEV1、PEF均高于对照组(t=6.591、9.615、11.383,均P<0.05)。治疗前,两组HMGB1、CRP、TNF-α水平差异均无统计学意义(t=0.306、0.669、0.371,均P>0.05);治疗后,两组HMGB1、CRP、TNF-α水平均下降(联合组:t=10.235、16.992、12.371,对照组:t=4.763、15.663、13.115,均P<0.05);治疗后,联合组HMGB1、CRP、TNF-α水平均低于对照组(t=6.591、3.559、8.307,均P<0.05)。结论 沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘急性发作的效果更佳,能有效改善患者肺功能,抑制炎性因子释放,且安全性高。
Objective To investigate the efficacy of salbutamol combined with budesonide aerosol inhalation in the treatment of patients with acute attack of bronchial asthma and its influence on serum inflammatory factors.Methods From January 2017 to December 2018,78 patients with acute attack of bronchial asthma in Zhejiang Xin'an International Hospital were selected,and they were divided into combined group and control group according to the random number table method,with 39 cases in each group.The control group was treated with routine western medicine,and the combined group was treated with salbutamol and budesonide aerosol inhalation on the basis of the control group.The two groups were treated for 2 weeks.The changes of vital capacity(VC),forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)were compared before and after treatment.The changes of serum high mobility group protein 1(HMGB1),C-reactive protein(CRP)and tumor necrosis factor-alpha(TNF-α)were measured before and after treatment.Results The total effective rate of the combined group was 87.18%(34/39),which was higher than 68.57%(24/39)of the control group,the difference was statistically significant(χ2=5.791,P<0.05).The values of VC,FEV1 and PEF between the two groups before treatment had no statistically significant differences(t=0.588,0.892,0.371,all P>0.05),which in the two groups after treatment were all increased(the combined group:t=16.045,7.193,6.667;the control group:t=7.834,8.354,4.262,all P<0.05).The values of VC,FEV1 and PEF in the combined group after treatment were higher than those in the control group(t=6.591,9.615,11.383,all P<0.05).The levels of HMGB1,CRP and TNF-αin the two groups before treatment had no statistically significant differences(t=0.306,0.669,0.371,all P>0.05),which in the two groups after treatment were all decreased(the combined group:t=10.235,16.992,12.371;the control group:t=4.763,15.663,13.115,all P<0.05).The levels of HMGB1,CRP and TNF-αin the combined group were lower than those in the control group after treatment(t=6.591,3.559,8.307,all P<0.05).Conclusion Salbutamol combined with budesonide aerosol inhalation in the treatment of acute attack of bronchial asthma has better effect,which can effectively improve the lung function of patients,inhibit the release of inflammatory factors,and with high safety.
作者
何丽丹
王锋
贾亮亮
He Lidan;Wang Feng;Jia Liangliang(Department of Respiratory Medicine,Zhejiang Xinan International Hospital,Jiaxing,Zhejiang 314013,China)
出处
《中国基层医药》
CAS
2020年第8期897-901,共5页
Chinese Journal of Primary Medicine and Pharmacy
