摘要
目的 探讨丙肝病毒核心抗原(HCV-cAg)检测的临床价值及其与HCV-RNA、ALT、AST的关系。方法 留取112例HCV-cAg检测阳性标本,205例丙肝病毒核心抗体(HCV-Ab)阳性标本,利用实时定量PCR法测定HCV-RNA,同时进行肝功能(ALT、AST)检测。结果 112例HCV-cAg阳性和205例HCV-Ab阳性标本中,HCV-RNA阳性分别为95例(阳性率84.8%)和142例(阳性率69.3%),前者显著高于后者(P<0.05);前者肝功能异常70例(占62.5%),后者肝功能异常95例(占46.3%),前者显著高于后者(P<0.05)。HCV-cAg结果S/CO值增高与HCV-RNA 阳性率和肝功能异常率呈正相关。结论 HCV-cAg检测阳性结果与HCV-RNA符合率高,并能够反应肝功能损伤程度,HCV-cAg检测对辅助临床诊疗具有重要的价值。
Objective To investigate the clinical value of detection of HCV-cAg and its relationship with HCVRNA,ALT and AST.Methods 112 HCV-cAg positive specimens and 205 HCV-Ab positive specimens were collected.Realtime Quantitative PCR method was used to detect HCV-RNA,and at the same time liver function(ALT,AST)was detected.Results There were 95 HCV-RNA-positive cases from the 112 HCV-cAg positive specimens(a positive rate of 84.8%)and 142 HCV-RNA-positive cases from 205 HCV-Ab positive specimens(a positive rate of 69.3%),respectively,and therewas significantly higher HCV RNA positive rate in the former than that in the latter(P<0.05);The former had 70 cases of abnormal liver function(62.5%)and the latter 95 cases(46.3%).The former was significantly higher than that of the latter(P<0.05).The increase of the value of S/CO in HCV-cAg results was positively correlated with the positive rate of HCV-RNA and the abnormal rate of liver function.Conclusion The positive results of HCV-cAg test highly correlate to HCV-RNA,and reflect the status of liver function.HCV-Ag test has important value in assisted clinical diagnosis.
作者
刘英超
张秋月
刘琳
任更朴
LIU Ying-chao;ZHANG Qiu-yue;LIU Lin(Department of Clinical Laboratory,The Second People's Hospital of Liaocheng,Liaocheng,The Second Hospital of Liaocheng affiliated to Shandong First Medical University,Shandong 252600)
出处
《临床输血与检验》
CAS
2020年第3期316-318,共3页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
丙型肝炎
丙肝病毒核心抗原
丙肝病毒核心抗体
丙肝病毒RNA
肝功能
Hepatitis C
Hepatitis C virus core antigen
Hepatitis C virus core antibody
Hepatitis C virus RNA
Liver function
作者简介
刘英超(1985-),男,山东临清人,主治医师,硕士,主要从事临床免疫与分子生物学检验,(Tel)15275667636(E-mail)yingchao621@163.com;通信作者:任更朴,男,主任技师,学士,主要从事临床免疫和生物化学检验,(E-mail)lceylyc@163.com。
