摘要
菌群移植(FMT)已成为治疗复发性艰难梭菌感染的有效手段,除此之外,在其他肠道及肠外疾病的治疗尝试中也显示出一定的效果,大量临床试验相继开展。关于FMT具体方法尚缺乏统一标准。本文从FMT适应证、供体筛选、菌液质量控制、FMT方法学、随访及疗效判断、不良反应处理以及伦理监管等方面,针对FMT目前存在的热点与争议问题,并结合本团队临床治疗经验做综合介绍。
Fecal microbiota transplant(FMT)has become an effective method for the treatment of recurrent C.difficile infection.In addition,it has shown certain effects in other diseases inside and outside the intestine.A large number of clinical trials have been carried out.However,there is still lack of uniform standard for strategies of FMT.In this paper,we discussed the current hot and controversial issues of FMT from the aspects of indication,donor screening,fecal suspension quality control,methodology,follow-up and efficacy judgment,treatment of adverse reaction and ethical supervision based on our team's clinical experience.
作者
张雪莹
陈启仪
李宁
秦环龙
Zhang Xueying;Chen Qiyi;Li Ning;Qin Huanlong(Intestinal Microenvironment Treatment Center,the Tenth People′s Hospital,Institute for Intestinal Diseases,Medical School of Tongji University,Shanghai 200072,China)
出处
《中华胃肠外科杂志》
CAS
CSCD
北大核心
2020年第5期509-515,共7页
Chinese Journal of Gastrointestinal Surgery
基金
上海市级医院新兴前沿技术联合攻关项目(SHDC12017112、SHDC12019114)。
关键词
菌群移植
适应证
供体筛选
质量控制
临床策略
Fecal microbiota transplantation
Indications
Donor screening
Quality control
Clinical strategy
作者简介
通信作者:秦环龙,Email:qinhuanlong@tongji.edu.cn。
