摘要
目的:探讨比阿培南联合莫西沙星治疗老年重症肺炎(SP)的临床效果。方法:回顾性选取2016年6月至2019年7月我院老年SP患者81例,按治疗方案不同分为3组,各27例。3组均实施常规治疗,对照1组予以比阿培南治疗,对照2组予以莫西沙星治疗,观察组予以比阿培南联合莫西沙星治疗。比较3组疗效、临床症状及体征改善时间、治疗前后病原菌检出率、炎性因子[血清降钙素原(PCT)、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)]、T淋巴细胞亚群(CD3、CD4、CD8)水平,统计3组不良反应发生情况。结果:观察组总有效率92.59%(25/27)高于对照1组、对照2组,治疗后革兰阴性菌检出率7.41%(2/27)低于对照1组、对照2组(P<0.05);观察组机械通气时间、退热时间、痰液性状改变时间、白细胞下降时间、肺部炎症明显吸收时间短于对照1组、对照2组(P<0.05);治疗后观察组血清PCT、WBC、hs-CRP水平低于对照1组、对照2组,CD3、CD4、CD8水平高于对照1组、对照2组(P<0.05);3组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:比阿培南联合莫西沙星治疗老年SP疗效显著,能有效抑制炎症反应,改善免疫功能,且不良反应少,安全性高。
Objective:To investigate the clinical effect of biapenem combined with moxifloxacin in the treatment of elderly severe pneumonia(SP).Methods:Eighty-one elderly patients with SP in our hospital from June 2016 to July 2019 were selected and divided into three groups according to different treatment,27 cases in each.All three groups were treated with routine treatment.The control group one was treated with biapenem,the control group two was treated with moxifloxacin,and the observation group was treated with biapenem combined with moxifloxacin.Comparison was made in fficacy,clinical symptoms and signs improvement time,detection rate of pathogenic bacteria before and after treatment,inflammatory factors[serum calcitonin(PCT),white blood cell count(WBC),high-sensitivity C-reactive protein(hs-CRP)],T-lymph Cell subsets(CD3,CD4,CD8)levels in three groups.The incidence of adverse reactions in the three groups was counted.Results:The total effective rate of observation group was 92.59%(25/27)higher than that of control group one and control group two.The detection rate of gram-negative bacteria after treatment was 7.41%(2/27)lower than that of control group one and control group two(P<0.05);mechanical ventilation time,antipyretic time,sputum trait change time,leukocyte decline time,and significant pulmonary inflammation absorption time in the observation group were shorter than those in control group one and control group two(P<0.05);After treatment,the levels of PCT,WBC and hs CRP in the observation group were lower than those in the control group one and two,and the levels of CD3,CD4 and CD8 were higher than those in the control group one and two(P<0.05).Conclusion:Biapenem combined with moxifloxacin has significant curative effect on elderly SP.It can inhibit the inflammatory response and improve immune function,with less adverse reactions and high safety.
作者
龚敬
陆伟
史刚
张肖难
刘丽
GONG Jing;LU Wei;SHI Gang(Suzhou Hospital Affiliated to Anhui Medical University/Suzhou Municipal Hospital,Anhui Suzhou 234000,China)
出处
《河北医学》
CAS
2020年第5期721-727,共7页
Hebei Medicine
基金
安徽省卫生厅科研课题,(编号:2018168209)。
作者简介
通讯作者:刘丽。
