摘要
母-胎界面免疫耐受是成功妊娠建立和维持的基础,T细胞是子宫蜕膜免疫细胞的重要组成细胞,既要介导抗感染免疫,保护胚胎免遭外来病原体攻击,同时又要参与母体接受同种异体胚胎的复杂免疫调节过程,在调控胚胎植入和维持妊娠过程中发挥重要作用,其功能失调可能会导致早期妊娠失败或中晚期妊娠并发症。本文就近年来关于妊娠期母-胎界面T细胞亚群的组成、表型特征及其功能进行介绍,并进一步阐述蜕膜CD4^+与CD8^+T细胞在母-胎免疫调节中的作用,以及异常调控致早期妊娠失败的分子机制,有助于深入理解母-胎免疫耐受机制,为妊娠相关疾病的防治提供新的线索。
Immune tolerance at maternal-fetal interface is the basis for establishment and maintenance of successful pregnancy. T cells are pivotal compositions of uterine decidual immune cells, which are required to mediate anti-infection immunity and protect embryos from external antigens attack. T cells also participate in the complex immune regulation process of maternal acceptance of semi-allogeneic embryos, and play an important role in regulating embryo implantation and maintaining pregnancy. Its dysfunction may lead to early pregnancy failures or mid-late pregnancy complications. This review summarizes the compositions, phenotypic characteristics and functions of decidual T cells at the maternal-fetal interface in recent years, and further describes the regulation of decidual CD4^+ and CD8^+ T cells in maternal-fetal immune tolerance as well as the molecular mechanisms of abnormal regulation leading to early pregnancy failures. Through the in-depth understanding the mechanism of maternal-fetal immune regulation, it supplies a novel concept on maternal-fetal immune tolerance and new clues for the immunotherapy of pregnancy-related diseases.
作者
黄茜茜
刘璐
王莉
杜美蓉
HUANG Xi-Xi;LIU Lu;WANG Li;DU Mei-Rong(Institute of Obstetrics and Gynecology,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China;Key Laboratory of Reproduction Regulation of the National Population and Family Planning Commission(NPFPC),Shanghai 200032,China;Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China;Department of Integrated Traditional and Western Medicine,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China)
出处
《生理学报》
CAS
CSCD
北大核心
2020年第1期11-19,共9页
Acta Physiologica Sinica
关键词
T细胞
母-胎界面
母-胎免疫耐受
妊娠相关疾病
T cells
maternal-fetal interface
maternal-fetal tolerance
pregnancy complications
作者简介
Corresponding authors.DU Mei-Rong:E-mail:mrdu@fudan.edu.cn;WANG Li:E-mail:wanglisa1101@163.com。
