摘要
Normal pregnancy is a contradictory and complicated physiological process.Although the fetus carries the human leukocyte antigen(HLA)inherited from the paternal line,it does not cause maternal immune rejection.As the only exception to immunological principles,maternal-fetal immune tolerance has been a reproductive immunology focus.In early pregnancy,fetal extravillous trophoblast cells(EVTs)invade decidual tissues and come into direct contact with maternal decidual immune cells(DICs)and decidual stromal cells(DSCs)to establish a sophisticated maternal-fetal crosstalk.This study reviews previous research results and focuses on the establishment and maintenance mechanism of maternal-fetal tolerance based on maternal-fetal crosstalk.Insights into maternal-fetal tolerance will not only improve understanding of normal pregnancy but will also contribute to novel therapeutic strategies for recurrent spontaneous abortion,pre-eclampsia,and premature birth.
基金
supported by the Key R&D Projects of Shaanxi Province(No.2021SF-005)
the Youth Independent Innovation Project of Tangdu Hospital(No.2023BTDQN020)
作者简介
Correspondence to:Xiaoming Zhu,Prof.,Department of Obstetrics and Gynaecology,Hainan Branch of PLA General Hospital,Sanya,Hainan 572013,China,E-Mail:xiaomingzhu1981@hotmail.com;Correspondence to:Tao Han,Prof.,Department of Orthopedics,Hainan Branch of PLA General Hospital,Sanya,Hainan 572013,China,E-Mail:hantao_16@163.com
