摘要
目的了解EB病毒(EBV)在体检人群中的感染及血清抗体情况,为临床进一步预防和治疗相关疾病提供理论依据。方法利用酶联免疫吸附测定对EBV相关抗体进行检测,利用SPSS20.0软件对数据进行统计学分析。结果2139例体检者共检测出血清抗体阳性2119例,总阳性率为99.06%。2019年EBV抗体衣壳抗原免疫球蛋白G(EBVCA-IgG)和核心抗原IgG(EBNA-IgG)抗体阳性率较高,分别为93.50%和92.15%,且EBVCA-IgG的阳性率在2017-2019年逐年上升。EBV-IgM阳性(即急性感染)所占比例为3.23%。≥50岁组EBV-IgM阳性率(3.14%)显著高于<50岁组(2.45%),差异有统计学意义(P<0.05)。结论本研究体检人群中EBV既往感染率在99.00%以上,且存在较高比例的急性感染情况(3.23%),尤其是中老年人急性感染率显著高于其他年龄。临床上应进一步重视和加强对相关人群尤其是中老年人EBV感染的筛查和监测。
Objective To understand the infection of Epstein-Barr virus(EBV)and the serum antibody in physical examination population,so as to provide a theoretical basis for further prevention and treatment of related diseases.Methods Enzyme linked immunosorbent assay was used to detect EBV related antibodies,and SPSS20.0 software was used to analyze the data.Results A total of 2139 physical examination population were tested for serum antibodies and 2119 were positive,the total positive rate was 99.06%.Among them,the positive rates of EBV antibody capsid antigen immunoglobulin G(EBVCA-IgG)and core antigen IgG(EBNA-IgG)antibodies were relatively high,at 93.50%and 92.15%,respectively,and the positive rate of EBVCA-IgG was increasing year by year from 2017-2019.The overall positive rate of EBV-IgM which reflected the acute infection was 3.23%.The total positive rate of EBV-IgM≥50 years old group(3.14%)was significantly higher than that of the group<50 years old group(2.45%),the difference was statistically significant(P<0.05).Conclusion The past infection rate of EBV in physical examination population is over 99.00%,and there is a high acute infection rate(3.23%),especially the acute infection rate of middle-aged and elderly people is significantly higher than other ages.Clinically,we should pay more attention to and strengthen the screening and monitoring of EBV infection in relevant populations,especially middle-aged and elderly people.
作者
刘杰
王利娟
谷愉愉
邵春青
康熙雄
张国军
LIU Jie;WANG Lijuan;GU Yuyu;SHAO Chunqing;KANG Xixiong;ZHANG Guojun(Department of Clinical Laboratory,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100070,China;Beijing Engineering Research Center of Immunological Reagents Clinical Research,Beijing 100070,China)
出处
《国际检验医学杂志》
CAS
2020年第10期1158-1160,共3页
International Journal of Laboratory Medicine
基金
北京市自然科学基金项目(7194261)。
关键词
体检人群
EB病毒
血清抗体
physical examination population
Epstein-Barr virus
serum antibody
作者简介
刘杰,男,主管技师,主要从事病原生物学相关研究;通讯作者:张国军,E-mail:tiantanzgj@163.com。
