摘要
目的对EB病毒(EPSTEIN-BARR,EB)阳性成人患者进行EB关联抗原、EB病毒DNA、常规血液学检查及血生化测试,深入解剖其临床表现,探讨该病毒在成年感染者中的临床表征。方法搜集本院呼吸科自2021年1月至2022年12月期间接收的214例成年EB病毒感染患者的临床资料与实验室检查数据,依据患者年龄进行分类,把年龄在20~59岁的患者纳为中青年组(共87例),把60岁以上的患者纳入老年组(共127例);收集50例同期进行健康检查人员,按前述年龄段分组法分为两个年龄对照组,青中年组31例,老年组17例。研究EB病毒在成年感染者中的临床表现,对比不同年龄层患者之间的差异与共性。结果214例EB病毒感染患者中,发生率最高的症状为高烧(共93例患者,占43.5%),其次为淋巴结肿大(共54例患者,占25.2%)、乏力(共30例患者,占14.1%)及皮疹(共16例患者,占7.5%);两组不同年龄段EB病毒感染患者,在实验室指标方面,除ALT、AST、GGT、ALP、TBLL、DBLL、IBLL对比无统计学意义,在白细胞计数、中性粒细胞计数、单核细胞计数及血小板计数方面,青中年组均高于老年组,P<0.05;在老年组比较中,两组除CD8+T淋巴细胞数绝对值无统计学意义,在其余指标比较中,EB病毒侵袭的老年群体各项指数普遍不及健康同龄者,相关数据对比,差异均有统计学意义(P<0.05);在中青年组比较中,两组除在NK细胞绝对数量上呈现显著统计学差异(P<0.05)外,其他结果比较,P>0.05;青年组与老年组EB病毒感染患者抗原、抗体和EB病毒DNA对比,P>0.05。结论感染EB病毒的成年人临床症状各异,其中中青年群体比老年人群更易出现明显的记忆性感染表现。同时,老年人群的细胞性及体液性免疫应答通常会出现受损降低的情况,与EB病毒相关的肿瘤在这一年龄段患者中所占比例则偏高。
Objective:To analyze the clinical manifestations of Epstein-Barr virus(EB)positive adult patients by EB-associated antigen,EB virus DNA,routine hematological examination and blood biochemical test,and to explore the clinical features of EB virus in adult infected patients.Methods:The clinical data and laboratory examination data of 214 adult patients with EB virus infection received by the respiratory department of our hospital from January 2021 to December 2022 were collected,and the patients aged 20~59 were classified into young and middle-aged group(87 cases)and patients over 60 were classified into elderly group(127 cases).50 health check-ups were collected and divided into two age control groups according to the above-mentioned age grouping method,31 cases in young and middle-aged group and 17 cases in elderly group.To study the clinical manifestations of EB virus in adult infected patients and compare the differences and commonness between patients of different ages.Results:Among 214 patients with EB virus infection,the highest symptom was high fever(93 patients,accounting for 43.5%),followed by lymphadenopathy(54 patients,accounting for 25.2%),fatigue(30 patients,accounting for 14.1%)and rash(16 patients,accounting for 7.5%).There was no significant difference in laboratory indexes between the two groups of patients with EB virus infection at different ages,except ALT、AST、GGT、ALP、TBLL、DBLL and IBLL.The white blood cell count,neutrophil count,monocyte count and platelet count in the young and middle-aged group were higher than those in the old group,P<0.05.In the comparison of the elderly group,there was no statistical significance between the two groups except for the absolute number of CD8+T lymphocytes.In the comparison of other indexes,the indexes of the elderly group infected by EB virus were generally lower than those of healthy people of the same age,and the differences were statistically significant,P<0.05.In the comparison between young and middle-aged groups,there was a significant statistical difference in the absolute number of NK cells between the two groups,P<0.05,and other results were compared,P>0.05;Comparison of antigen,antibody and EB virus DNA between young group and old group,P>0.05.Conclusion:Adults infected with EB virus have different clinical symptoms,among which young and middle-aged people are more likely to have obvious manifestations of memory infection than the elderly.At the same time,the cellular and humoral immune responses of the elderly population are usually impaired and reduced,and the proportion of tumors related to EB virus is high in this age group.
作者
张红
王佳
盛玉杰
朱佳慧
Zhang Hong;Wang Jia;Sheng Yujie;Zhu Jiahui(Department of Infectious Diseases Qinhuangdao First Hospital,Qinhuangdao He Bei 066000,China)
出处
《生命科学仪器》
2024年第2期48-51,共4页
Life Science Instruments
基金
秦皇岛市科学技术研究与发展计划项目(编号:202101A193)。
关键词
成人EB病毒感染
临床特征
实验室特征
Adult
EB viral infection
Clinical characteristics
Laboratory characteristics
作者简介
张红(1982-10-29)女,汉族,职称:主治医师,研究方向:EB病毒。
