摘要
目的对天津市确诊新型冠状病毒肺炎病例治愈出院后病毒核酸重新转阳病例进行分析。方法对中国疾病预防控制信息系统报告的天津市确诊新型冠状病毒肺炎109例出院患者中,8例核酸重新转阳的病例进行监测,包括病例流行病学史、发病时间、临床表现等调查并定期病毒核酸检测,分析流行病学特征。结果截至2020年3月7日,天津市确诊新型冠状病毒肺炎病例康复出院后病毒核酸转阳率为7.34%(8/109)。病毒核酸阳性的8例病程中位时间为20.5(14.0~28.0)d,与病毒核酸阴性病例相比差异无统计学意义。8份病毒核酸阳性样本中粪便标本或肛拭子占62.50%(5/8),咽拭子占37.50%(3/8)。8例病例均有明确的流行病学史,核酸重新转阳时12.5%(1/8)出现临床症状,但均未造成续发传播。结论天津市新型冠状病毒肺炎病例出院后存在病毒核酸重新转阳的现象,未造成续发传播。建议治愈、隔离观察前增加粪便核酸检测指标,病例出院后定期进行核酸检测。
Objective To analyze the re-positive nucleic acid cases in patients recovered from coronavirus disease 2019(COVID-19)in Tianjin,and to provide suggestions on making prevention and control strategies.Methods Among the 109 confirmed COVID-19 patients in Tianjin who were reported by the China Information System for Disease Control and Prevention,8 patients re-positive for nucleic acid test after discharge were enrolled in this study.Their conditions after discharge were monitored by our group,including epidemiology,onset time,symptoms,and results of regular viral nucleic acid test.The epidemiological characteristics were analyzed.Results As of March 7,2020,the positive rate of re-positive nucleic acid conversion in patients recovered from COVID-19 was 7.34%(8/109).The median days of disease was 20.5(14.0~28.0)d in 8 re-positive cases,which was not statistically different from those with negative results after discharge.Among the viral nucleic acid-positive samples,fecal specimens or anal swabs accounted for 62.50%(5/8),and throat swabs for 37.50%(3/8).All 8 cases had identified epidemiological history.When the nucleic acid re-positive,12.50%of them(1/8)had clinical symptoms,but they did not cause any secondary transmission.Conclusion Re-positiveness for nucleic acid test are found in the COVID-19 patients after discharge in Tianjin,but no one causes further transmission till now.It is recommended to add standards for fecal nucleic acid test during discharge and quarantine,regularly nucleic acid detection after the patient is discharged from the hospital.
作者
赵莹
吴伟慎
何海艳
魏兆飞
张国平
ZHAO Ying;WU Weishen;HE Haiyan;WEI Zhaofei;ZHANG Guoping(Epidemiology Working Group for COVID-19,Tianjin Center for Disease Control and Prevention,Tianjin,300011,China)
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2020年第9期879-882,共4页
Journal of Third Military Medical University
基金
天津市新型冠状病毒感染应急防治科技重大专项(2020)
天津市卫生健康委新冠肺炎防治科技项目(2020)。
作者简介
通信作者:吴伟慎,E-mail:wuweishen@live.cn。
