摘要
目的:探讨支架辅助颅内动脉瘤栓塞中替罗非班的安全性及有效性。方法:选取2017年10月至2018年10月100例颅内动脉瘤患者,分组方式为随机数字表法,对照组(n=50)静脉泵入大剂量替罗非班,观察组(n=50)静脉泵入小剂量替罗非班,分析术后即刻栓塞程度、并发症发生率、凝血指标变化情况以及出院时临床预后。结果:观察组术后即刻栓塞程度、相关并发症发生率相较于对照组低,出院时临床预后高于对照组,P<0.05。结论:支架辅助颅内动脉瘤栓塞中应用小剂量替罗非班效果较好,可有效降低相关并发症发生率,改善患者预后。
Objective:To investigate the safety and efficacy of tirofiban in stent-assisted intracranial aneurysm embolization.Methods:One hundred patients with intracranial aneurysms from October 2017 to October 2018 were enrolled in a randomized digital table.The control group(n=50)received a large dose of tirofiban intravenously.The observation group(n=50)Intravenous infusion of low-dose tirofiban,analysis of immediate embolization,complication rate,changes in coagulation parameters and clinical prognosis at discharge.Results:The degree of embolization and the incidence of related complications were lower in the observation group than in the control group.The clinical prognosis at discharge was higher than that in the control group(P<0.05).Conclusion:The use of low-dose tirofiban in stent-assisted intracranial aneurysm embolization is effective,which can effectively reduce the incidence of related complications and improve the prognosis of patients.
作者
刘刚
LIU Gang(Interventional Department,Luohe Central Hospital,Luohe Henan 462000,China)
出处
《药品评价》
CAS
2020年第4期37-38,共2页
Drug Evaluation
关键词
支架辅助栓塞
颅内动脉瘤
替罗非班
安全性
有效性
Stent-assisted Embolization
Intracranial Aneurysm
Tiropheban
Security
Effectiveness
作者简介
刘刚,副主任医师,研究方向:神经介入、外周血管介入、肿瘤微创介入。E-mail:tm101101@126.com。
