摘要
线粒体是调节细胞能量平衡的关键细胞器,其在细胞代谢、应激反应和细胞死亡中具有重要意义。而在内外环境的影响下,受损或衰老的线粒体对细胞生存造成严重威胁。线粒体自噬是指细胞选择性消除功能失调的线粒体,从而维持细胞内环境稳定。FUNDC1是新近发现的一种线粒体自噬受体蛋白,在介导线粒体自噬方面发挥重要调节作用。文章主要就近年来线粒体自噬中FUNDC1调控机制及其病理生理意义的研究进展进行综述。
Mitochondria,which play an important role in cell metabolism,stress response and cell death,are the key organelles that regulate the energy balance of cells.Under the influence of internal and external environment,damaged or senescent mitochondria pose a serious threat to cell survival.Mitophagy refers to the selective elimination of dysfunctional mitochondria to maintain the homeostasis of the intracellular environment.FUN14 domain containing 1(FUNDC1)is a newly discovered mitophagy receptor protein,which plays an important regulatory role in mediating mitophagy.This paper mainly reviews the recent research progress of FUNDC1 regulation mechanism and its pathophysiological significance in mitophagy.
作者
罗以楠(综述)
邱俏檬
卢中秋
姚咏明(审校)
LUO Yi-nan(reviewing);QIU Qiao-meng;LU Zhong-qiu;YAO Yong-ming(checking)(Department of Emergency,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China;Trauma Research Center,Fourth Medical Center of the Chinese PLA General Hospital,Beijing 100048,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第5期537-542,共6页
Journal of Medical Postgraduates
基金
国家自然科学基金(81772112)。
作者简介
罗以楠,医学硕士研究生;通信作者:邱俏檬,E-mail:qqm@wzhospital.cn。
