摘要
目的观察心房颤动(房颤)患者血清25羟基维生素D[25(OH)D]、白细胞介素-10(IL-10)、左心房直径(LAD)的变化,并探讨其与房颤的关系。方法选取2011年12月~2012年12月四川省自贡市第一人民医院(以下简称"我院")心血管内科接收的房颤患者111例作为研究组,其中阵发性房颤20例,持续性房颤40例,永久性房颤51例。另选取同期我院心血管内科住院治疗的非房颤患者109例作为对照组。ELISA法检测血清25(OH)D、IL-10,超声心动图测量LAD,并对其进行比较。结果研究组25(OH)D、IL-10水平明显低于对照组,LAD高于对照组,差异均有统计学意义(均P <0.05)。研究组不同房颤类型患者血清25(OH)D、IL-10水及LAD比较,差异均有统计学意义(均P <0.05)。与持续性房颤组比较,永久性房颤组25(OH)D和IL-10水平降低、LAD升高,差异均有统计学意义(均P <0.05);与阵发性房颤组比较,持续性房颤动组和永久性颤动组25(OH)D和IL-10水平降低、LAD升高,差异均有统计学意义(均P <0.05)。结论房颤患者25(OH)D、IL-10、LAD与房颤的发生发展关系密切。
Objective To observe the changes of serum 25-hydroxivitamin D [25(OH)D], interleukin-10(IL-10) and left atrial diameter(LAD) in patients with atrial fibrillation, and to explore their relationship with atrial fibrillation.Methods A total of 111 patients with atrial fibrillation admitted to the Department of Cardiovascular Medicine, Zigong First People′s Hospital(hereinafter referred to as "our hospital") from December 2011 to December 2012 were selected as the research group, including 20 patients with paroxysmal atrial fibrillation, 40 patients with persistent atrial fibrillation and 51 patients with permanent atrial fibrillation. Another 109 cases of non-atrial fibrillation patients hospitalized in the Department of Cardiovascular Medicine of our hospital at the same time were selected as the control group.Serum 25(OH)D and IL-10 were detected by ELISA, LAD was measured by echocardiography and they were compared.Results The levels of 25(OH)D and IL-10 in the study group were significantly lower than those in the control group, and the LAD was higher than that in the control group, with statistically significant differences(all P < 0.05). Serum25(OH)D and IL-10 levels and LAD of patients with different atrial fibrillation types in the study group showed statistically significant differences(all P < 0.05). Compared with the persistent atrial fibrillation group, 25(OH)D and IL-10 levels decreased and LAD increased in the permanent atrial fibrillation group, with statistically significant differences(all P < 0.05). Compared with the paroxysms atrial fibrillation group, 25(OH)D and IL-10 levels decreased and LAD increased in the persistent atrial fibrillation group and permanent atrial fibrillation group, with statistically significant differences(all P <0.05). Conclusion In patients with atrial fibrillation, 25(OH)D, IL-10, and LAD are closely related to the occurrence and development of atrial fibrillation.
作者
曹文斋
张婷
曾锐
CAO Wenzhai;ZHANG Ting;ZENG Rui(Department of Cardiovascular Medicine,Zigong First People′s Hospital,Sichuan Province,Zigong 643000,China;Department of Nursing,Sichuan Vocational College of Health and Rehabilitation,Sichuan Province,Zigong 643000,China;Department of Cardiovascular Medicine,West China Hospital of Sichuan University,Sichuan Province,Chengdu 610041,China)
出处
《中国医药导报》
CAS
2020年第10期78-81,共4页
China Medical Herald
基金
四川大学-自贡市校地合作专项基金项目(2018 CDZG-21)
四川省教育厅课题(18ZB0504)
四川省医学会课题(S17085、2018SHD2-5)
四川卫生康复职业学院课题(CWKY-2019Y-02)。
作者简介
曹文斋(1982-),男,博士,浙江大学医学院2019级临床医学专业在读博士后,副主任医师,硕士生导师,研究方向:心房颤动疾病的基础及临床研究。
