摘要
本科生创新能力培养是“双一流”建设人才培养的重要组成部分。合成生物学是一门新兴多学科交叉领域,被誉为可改变世界的十大新技术领域之一。构建高版本底盘微生物细胞和利用底盘细胞人工合成细胞工厂是合成生物学的重要组成部分。以实现创新型本科生为培养目标,我们将合成生物学底盘微生物细胞技术融入人才培养环节,通过组织学生参加国际遗传工程机器设计竞赛、主持大学生创新创业训练项目以及完成本科生毕业设计课题等多元化途径,提高学生理论联系实际及创新实践能力。同时,由于底盘微生物细胞是基因组经过精简、优化或其基因通路被改变的细胞,其应用存在一定的生物安全风险。我们通过将安全教育纳入培养大纲和教学计划、出版实验室安全与操作规范专业教材、开发虚拟仿真实验项目、建立实验室准入制度和信息化管理体系,以及针对底盘微生物细胞从购买、管理、规范使用和废弃物处理等进行生物安全教育等系列举措,规范底盘微生物细胞应用的生物安全。这些实践为培养创新型本科生提供了一个强有力的途径和有效保障,也为合成生物学的发展提供了支持,并有助于培养新的生力军。
The cultivation of undergraduate innovation ability is an important content of the cultivation of undergraduate talents in the“double first-class”construction.Synthetic biology is a new field of cross-disciplinary biology,which is praised as one of the ten new technology fields that can change the world.It is an important content of synthetic biology to construct high version classis microbial cells and to use chassis cells to synthesize cell factories.With the goal of cultivating innovative undergraduates,we integrate synthetic biology chassis microbial cell technology into the talent cultivation process.By organizing students to participate in International Genetically Engineered Machine Competition,to preside over Undergraduate Innovation and Entrepreneurship projects and to complete undergraduate graduation design projects,the students’ability of linking theory with practice and innovation ability is improved.Moreover,as chassis microbial cell is a kind of cell whose genome has been simplified or optimized or its gene pathway has been changed,its application also brings certain biosafety risks.We standardize biosafety of chassis microbial cells by a serial of measures including bringing safety education into the training syllabus and teaching plan,publishing professional textbooks related with laboratory safety and operation procedures,developing virtual simulation experiment projects,setting up the lab access system and the information management system,and carrying out biosafety education on chassis microbial cells from purchase,management,standardized use and waste disposal.These practices provide a powerful way and effective guarantee for cultivating innovative undergraduates,and also provide support for the development of synthetic biology and cultivate new forces.
作者
曾小美
苏莉
刘亚丰
谢尚县
ZENG Xiao-Mei;SU Li;LIU Ya-Feng;XIE Shang-Xian(College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China)
出处
《微生物学通报》
CAS
CSCD
北大核心
2020年第4期1224-1229,共6页
Microbiology China
基金
国家重点研发计划(2018YFA0902400)。
关键词
创新型本科生
底盘微生物细胞
合成生物学
生物安全
实践
Innovative undergraduate students
Classis microbial cells
Synthetic biology
Biosafety
Practice
作者简介
通信作者:曾小美,E-mail:xmzeng@hust.edu.cn,Tel:027-87792072;通信作者:苏莉:E-mail:lisu@hust.edu.cn。
