摘要
目的:观察儿童维生素A(VA)缺乏情况与肺炎支原体肺炎(M PP)病情程度的相关性。方法:纳入徐州市中心医院2017年1月至2019年7月确诊为M PP住院患儿300例为研究对象,按照病情程度将其分为普通M PP组(220例)与难治性M PP组(即RM PP组,80例)。对比两组VA及免疫球蛋白水平,观察两组临床型VA缺乏(CVAD)、亚临床型VA缺乏(SVAD)+VA正常检出情况,并分析VA缺乏与RM PP患儿合并感染及免疫球蛋白水平的关系。结果:普通M PP组VA水平显著高于RM PP组(P<0.05),CVAD检出率及IgM、IgA、IgG水平显著低于RM PP组(P<0.05)。RM PP组合并感染27例,占33.75%;未合并感染53例,占66.25%;RM PP合并感染者CVAD检出率显著高于RM PP未合并感染者(P<0.05)。RM PP患儿中CVAD组IgM、IgA水平显著高于SVAD+VA正常组(P<0.05)。结论:VA缺乏与M PP病情程度相关,临床上应引起足够重视。
Objective:To observe the correlation between vitamin A(VA)deficiency and the severity of M PP in children.Methods:300 cases of hospitalized children diagnosed with M PP in Cangzhou People's Hospital from March tudied,and they were divided into M PP group(220 cases)and 2017 to August 2018 were s refractory M PP group(RM PP group,80 cases)according to the degree of illness.VA and immunoglobulin levels in the two groups were compared to observe the normal detection of clinical VA deficiency(CVAD)and subclinical VA deficiency(SVAD)+VA in the two groups,and analyze the relationship between VA deficiency and co-infection and immunoglobulin levels in the children with RM PP.Results:The VA level of common MPP group was significantly higher than that of RM PP group(P<0.05),and the detection rate of CVAD and the levels of IgM,IgA and IgG were significantly lower than that of RM PP group(P<0.05).RM PP combined with infection was found in 27 cases(33.75%)and 53 cases without infection(66.25%);The detection rate of CVAD in RMPP with infection was significantly higher than that in RMPP without infection(P<0.05).The levels of IgM and IgA in CVAD group were significantly higher than those in SVAD group and VA normal group(P<0.05).Conclusion:VA deficiency is related to the severity of M PP,which should be paid enough attention in clinic.
作者
宋晓彤
孙迎军
张艳
SONG Xiaotong;SUN Yingjun;ZHANG Yan(Xuzhou Central Hospital, Jiangsu Xuzho 221009, China)
出处
《河北医学》
CAS
2020年第4期653-656,共4页
Hebei Medicine
基金
江苏省自然科学基金青年项目,(编号:BK20160612)。
关键词
儿童维生素A
肺炎支原体肺炎
病情程度
相关性
Children's vitamin A
Mycoplasma pneumoniae pneumonia
Severity
The correlation
