摘要
近年来的研究表明,肠道微生物群的生态失调、炎性反应和黏膜免疫功能受损是NAFLD发生发展的重要因素。调节肠道菌群是治疗非酒精性脂肪肝的重要策略和治疗靶位之一,具有良好的前景。现综述通过调节肠道菌群治疗非酒精性脂肪肝的研究进展,如益生菌、抗生素、黏附分子、肠菌移植,以及中医药在非酒精性脂肪肝中的应用研究。
Recent studies have shown that ecological imbalance of intestinal microbiota,inflammation and impaired mucosal immune function are important factors for the occurrence and development of NAFLD.This paper reviews the research progress in the treatment of non-alcoholic fatty liver by regulating intestinal microbiota,such as probiotics,antibiotics,adhesion molecules,intestinal bacteria transplantation,and the application of traditional Chinese medicine in non-alcoholic fatty liver.The authors believes that the regulation of intestinal microbiota is one of the important strategies and targets for the treatment of non-alcoholic fatty liver and has a good prospect.
作者
刘巧红
赵瑜
胡义扬
LIU Qiao Hong;ZHAO Yu;HU Yiyang(Shuguang Hospital & Institute of Hepatology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Clinical Research Center,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China)
出处
《世界中医药》
CAS
2020年第7期1075-1079,共5页
World Chinese Medicine
基金
国家自然科学基金重点项目(81830119)
上海申康三年行动计划(16CR1019A)。
关键词
肠道菌群
非酒精性脂肪性肝病
研究进展
益生菌
抗生素
黏附分子
肠菌移植
中药
Intestinal microbiota
Non-alcoholic fatty liver disease
Research progress
Probiotics
Antibiotics
Adhesion molecules
Enterobacteria transplantation
Traditional Chinese medicine
作者简介
刘巧红(1991.04—),女,博士研究生,研究方向:中医内科肝病,E-mail:1163844112@qq.com;通讯作者:胡义扬(1962.08—),男,博士,主任医师,研究方向:中医内科肝病,E-mail:yyhuliver@163.com。
