摘要
目的分析慢性高血压并发子痫前期孕妇产前血清肌酐水平与围产儿结局的相关性。方法回顾性分析2012年10月至2017年10月在广州医科大学附属第三医院诊断为慢性高血压并发子痫前期的患者88例,根据产前血清肌酐水平分为高血肌酐组(n=27)和正常血肌酐组(n=61),比较两组孕妇围产儿结局。结果高血肌酐组出生体质量<2500 g和<1500 g的新生儿比例高于正常血肌酐组(P<0.05);两组新生儿黄疸、贫血、酸中毒、视网膜病、呼吸系统发育不良的结局分析,差异均有统计学意义(P<0.05)。高血肌酐组的早产儿发生率、转新生儿科率高于正常血肌酐组(P<0.05);两组胎儿窘迫、胎儿生长受限、死胎、新生儿死亡、新生儿呼吸窘迫综合征和暂时性凝血功能障碍指标比较差异无统计学意义。结论血肌酐水平在一定程度上可作为慢性高血压并发子痫前期早产与新生儿并发症的检测指标。
Objective To analyze the correlation between prenatal serum creatinine level and perinatal outcome in pregnant women with chronic hypertension complicating with preeclampsia.Methods 88 cases of patients with chronic hypertension complicating with preeclampsia diagnosed in the Third Affiliated Hospital of Guangzhou Medical University from October 2012 to October 2017 were retrospectively analyzed.According to prenatal serum creatinine,they were divided into high serum creatinine group(n=27)and normal serum creatinine group(n=61),compared the perinatal outcome between two groups.Results The proportions of children with birth weight<2500 g and<1500 g in high serum creatinine group were higher than that in normal creatinine group(P<0.05).The outcomes of neonatal jaundice,anemia,acidosis,retinopathy,respiratory dysplasia between the two groups were compared,the difference was statistically significant(P<0.05).The incidences of premature and neonatal conversion rate in high serum creatinine group were higher than those in normal serum creatinine group(P<0.05).Fetal distress,fetal growth restriction(FGR),stillbirth,induced labor,neonatal mortality,neonatal respiratory distress syndrome and temporary coagulation dysfunction between the two groups were compared,the difference was not statistically significant.Conclusion Serum creatinine level can be used as an indicator of premature and neonatal complications in patients with chronic hypertension complicated by preeclampsia.
作者
陈艳红
王森兰
麦美珊
周友钧
莫文燕
王小莉
Chen Yanhong;Wang Senlan;Mai Meishan;Zhou Youjun;MoWenyan;Wang Xiaoli(Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Guangzhou Higher Medica University,Guangzhou,Guangdong,510150,China;the Third Clinical College of Guangzhou Higher Medical University,Guangzhou,Guangdong,510180,China)
出处
《当代医学》
2020年第12期19-21,共3页
Contemporary Medicine
基金
广东省医学科研基金(A2018147)
广州医科大学第三临床学院大学生科研项目基金(2018A0025)
广东省临床教学基地教学改革研究项目基金(2018JD033)。
关键词
慢性高血压并发子痫前期
血清肌酐
围产儿结局
Chronic hypertension complicating with preeclampsia
Serum creatinine
Perinatal outcome
作者简介
第一作者和通讯作者:陈艳红,E-mail:31544887@qq.com;第一作者:王森兰;通讯作者:王小莉,E-mail:violin1015@163.com。
