摘要
目的探究血清S100β、胱抑素C(Cys-C)评估老年急性脑梗死(ACI)患者疾病严重程度及预测出血转化的价值。方法回顾性分析我院2018年1月至2019年10月期间收治的100例老年ACI患者的临床病历资料,根据入院时美国国立卫生研究院卒中量表(NIHSS)评分结果将患者分为轻度组(1-4分)39例、中度组(5-15分)29例、重度组(16-42分)32例,按梗死面积大小将纳入患者分为腔隙性梗死组(面积≤1.5 cm^2)37例、小面积梗死组(1.5 cm^2<面积≤5 cm^2)30例、大面积梗死组(面积>5 cm^2)33例,另选取同期进行体检的60例老年健康人群作为对照组,比较各组血清S100β、Cys-C水平。结果ACI组血清S100β、Cys-C水平高于对照组(P<0.05);重度组血清S100β、Cys-C水平高于中度组、轻度组(P<0.05),中度组血清S100β、Cys-C水平高于轻度组(P<0.05);大面积梗死组血清S100β、Cys-C水平高于小面积梗死组、腔隙性梗死组(P<0.05),小面积梗死组血清S100β、Cys-C水平高于腔隙性梗死组(P<0.05);出血转化组血清S100β、Cys-C水平高于未出血转化组(P<0.05);受试者工作特征曲线(ROC)分析结果提示,联合检测预测出血转化AUC为0.924大于S100β、Cys-C单一检测的0.767、0.661。结论血清S100β、Cys-C可用于评估老年ACI患者疾病严重程度,可有效预测出血转化。
Objective To explore value of serum S100β and cystatin-C(Cys-C)in evaluating disease severity and predicting hemorrhagic transformation(HT)in elderly patients with acute cerebral infarction(ACI).Methods The clinical medical data of100 elderly ACI patients who were admitted to the hospital from January 2018 to October 2019 were retrospectively analyzed.According to scores of National Institutes of Health Stroke Scale(NIHSS)at admission,they were divided into mild group(1-4 points,39 cases),moderate group(5-15 points,29 cases)and severe group(16-42 points,32 cases).According to different size of infarct areas,they were divided into lacunar infarction group(area less than 1.5 cm2,37 cases),small-area infarction group(area more than 1.5 cm^2 and not more than 5 cm2,30 cases)and large-area infarction group(area more than 5 cm^2,33 cases).Sixty healthy elderly people in the same period were enrolled as control group.The levels of serum S100β and Cys-C were compared among all groups.Results The levels of serum S100β and Cys-C in ACI group were higher than those in control group(P<0.05).The levels of serum S100β and Cys-C were the highest in severe group,followed by moderate group and mild group(P<0.05).The levels of serum S100β and Cys-C were the highest in large-area infarction group,followed by small-area infarction group and lacunar infarction group(P<0.05).Pearson correlation analysis showed that there was significant positive correlation between serum S100β and Cys-C in elderly ACI patients(r=0.541,P<0.05).The levels of serum S100β and Cys-C in HT group were higher than those in non-HT group(P<0.05).The analysis results of receiver operating characteristic(ROC)curves suggested that AUC of combined detection for predicting HT was greater than that of S100β and Cys-C(0.924 vs 0.767,0.661).Conclusion Serum S100β and Cys-C can be applied to evaluate disease severity of elderly ACI patients,and can effectively predict HT.
作者
沈小平
宋元清
高慧
王士列
SHEN Xiaoping;SONG Yuanqing;GAO Hui(Department of Neurology,Jiujiang Hospital Affiliated to Nanchang University,Jiujiang 332000,China)
出处
《江西医药》
CAS
2020年第4期390-393,共4页
Jiangxi Medical Journal
