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PDX模型在妇科恶性肿瘤靶向治疗方面的应用 被引量:1

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摘要 人源性肿瘤异种移植(PDX)模型是将患者的肿瘤组织或细胞经处理后移植到免疫缺陷小鼠上所建立的模型。PDX模型能较好保留原始肿瘤的组织学、分子学及遗传学特性,因此具有优于传统体外细胞系及其衍生物的特点,常被作为癌症患者的替代模型用于临床前药物筛选。本文从PDX模型的建立及其在妇科恶性肿瘤的靶向治疗方面进行综述,明确其在妇科恶性肿瘤靶向治疗方面的应用价值。
出处 《现代妇产科进展》 CSCD 北大核心 2020年第4期308-312,共5页 Progress in Obstetrics and Gynecology
基金 温州市重大科技专项资助(No:ZS2017006).
作者简介 通讯作者:朱雪琼,Email:zjwzzxq@163.com。
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