摘要
目的探讨胸腺肽注射液辅助化疗对卵巢癌患者免疫功能及生命质量的影响。方法选取206例卵巢癌患者为研究对象，按随机数字表法分为观察组与对照组，各103例，对照组接受单纯化疗，观察组在单纯化疗的基础上配合胸腺肽注射液治疗，比较两组患者的免疫功能及生命质量。结果观察组患者总有效率及疾病控制率均优于对照组[44．66％（46／103）比30．10％（31／103），86．41％（89／103）比66．99％（69／103）]，差异均有统计学意义（Х^2=3．942、4．138，P=0．022、0．015）；观察组不良反应发生例数少于对照组（22例比35例），差异有统计学意义（Yz=3．601，P=0．026）；观察组患者生命质量改善率优于对照组[60．19％（62／103）比40．78％（42／103）]，差异有统计学意义（Х^2=3．974，P=0．021）。治疗后，观察组患者免疫球蛋白IgA、IgG、IgM水平及T淋巴细胞CD3、CD4、NK细胞水平及CD4／CD8值均高于对照组，差异均有统计学意义（均P〈0．05）。结论胸腺肽注射液辅助化疗有助于提高卵巢癌患者的免疫功能，改善患者的生命质量，值得临床推广应用。
Objective To investigate the influence of thymosin injection combined with chemotherapy on the immune function and quality of life in patients with ovarian cancer. Methods A total of 206 patients with ovarian cancer were chosen and were divided into the control group （n = 103） and the observation group （n = 103） according to the random number table. The control group received chemotherapy. Based on the treatment of control group, the observation group was additionally treated with thymosin injection, the immune function and quality of life were analyzed and compared between two groups. Results The rates of effectivity and disease control were higher in the observation group than those in the control group [44.66 % （46/103） vs 30.10 % （31/103）, 86.41% （89/103） vs 66.99 % （69/103）], the differences were statistically significant （X2 = 3.942, 4.138, P = 0.022, 0.015）, and number of cases of adverse reactions were lower in observation group than those in the control group （22 cases vs 35 cases, Х^2= 3.601, P = 0.026）, and the improvement rate of quality of life of patients were higher in the observation group than that in the control group [60.19 % （62/103） vs 40.78 % （42/103）, Х^2 = 3.974, P = 0.021]. After treatment, the expression levels of IgA, IgG, IgM and CD3, CD4, CD4/CD8, NK cells were significantly higher in the observation group than those in the control group, the difference was statistically significant （all P 〈 0.05）. Conclusion Thymosin injection combined with chemotherapy is helpful to improve the immune function and the quality of life in patients with ovarian cancer, it is worthy of wider promotion and application.
出处
《肿瘤研究与临床》
CAS
2016年第1期48-51,共4页
Cancer Research and Clinic
关键词
卵巢肿瘤
胸腺肽注射液
药物疗法
免疫功能
生命质量
Ovarian neoplasms
Thymosin injection
Drug therapy
Immune function
Quality of life
作者简介
通信作者：程越，Email：chengyue5911@163．com
