摘要
目的观察联合应用沙格列汀和二甲双胍对不同病程2型糖尿病(T2DM)患者胰岛功能的影响。方法选取2016年1月~2018年12月120例单药应用二甲双胍血糖控制不达标的T2DM患者,根据发病时间分为短病程组(0~3年)共60例,长病程组(3~10年)共60例,两组加用沙格列汀治疗24周,观察两组血糖、糖化血红蛋白(HbA1C)、稳态模型β细胞功能指数(HOMA-β)、体重指数(BMI)等指标。结果两组治疗后空腹血糖(FPG)、餐后2h血糖(2h PG)、HbA1C、稳态模型胰岛素抵抗指数(HOMA-IR)、BMI、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均较治疗前显著下降,HOMA-β升高,差异均有统计学意义(P<0.05);与长病程组比较,短病程组的FPG、2h PG、HbA1C、LDL-C降低更明显,HOMA-β升高的幅度更显著[短病程HOMA-β升高幅度(25.93±0.78),长病程HOMA-β升高幅度(13.81±1.69),t=50.438,P=0.000]。结论不同病程的T2DM患者联合应用沙格列汀和二甲双胍治疗,降糖疗效明显,有效改善胰岛素β细胞功能,减轻胰岛素抵抗,降低体重,早期应用获益更多。
Objective To observe the effects of combined application of saxagliptin and metformin on islet function in patients with type 2 diabetes mellitus(T2DM)of different courses.Methods 120 patients with T2DM who were treated with metformin alone and did not reach the standard of blood glucose control from January 2016 to December 2018 were selected and divided into the short-course group(0-3 years)with 60 patients in total and the long-course group(3-10 years)with 60 patients in total according to the onset time.The two groups were treated with saxagliptin for 24 weeks,and the indexes such as blood glucose,glycosylated hemoglobin(HbA1C),homeostasis model assessment ofβ-cell function(HOMA-β),body mass index(BMI),etc.were observed in the two groups.Results After treatment,fasting plasma glucose(FPG),2-hour postprandial blood glucose(2h PG),HbA1C,homeostasis model assessment of insulin resistance(HOMA-IR),BMI,triglyceride(TG),and low-density lipoprotein cholesterol(LDL-C)of the two groups all decreased significantly compared with those before treatment,while HOMA-βincreased(P<0.05);Compared with the long-course group,FPG,2h PG,HbA1C and LDL-C in the short-course group decreased more significantly,while HOMA-βincreased more significantly[the short-course HOMA-βincreased by(25.93±0.78),and the long-course HOMA-βincreased by(13.81±1.69),t=50.438,P=0.000].Conclusion The combination of saxagliptin and metformin in the treatment of patients with T2DM of different courses has an obvious hypoglycemic effect,effectively improving the function of insulinβ-cells,alleviating insulin resistance,reducing body weight,and benefiting more from early application.
作者
钟钻仪
张慧芬
陈中
ZHONG Zuanyi;ZHANG Huifen;CHEN Zhong(Department of Endocrinology,Dongguan Traditional Chinese Medicine Hospital,Dongguan 523000,China)
出处
《中国医药科学》
2020年第5期58-61,共4页
China Medicine And Pharmacy
关键词
2型糖尿病
沙格列汀
病程
胰岛功能
血糖
Type 2 diabetes mellitus
Saxagliptin
Courses
Islet function
Blood glucose
