摘要
为了寻找具有较好生物活性的吡唑肟醚类衍生物,基于唑螨酯的结构,在吡唑环的4-位引入1,3,4-噁二唑结构,设计合成了15个结构新颖的吡唑肟醚类化合物,它们的结构通过1H NMR、13C NMR、元素分析等手段得到表征.生测研究表明,部分目标化合物在500和100μg/mL浓度下对粘虫(Oriental armyworm)或蚜虫(Aphis medicaginis)都有较好的杀虫效果,其中10a, 10e, 10f和10j在100μg/mL时对粘虫有100%的杀死率, 10g, 10j和10l在100μg/mL时对蚜虫有100%的杀虫活性.另外, 10l在500μg/mL浓度下对朱砂叶螨(Tetranychus cinnabarinus)也具有100%的杀灭效果.
In search of novel pyrazole oxime ether derivatives with potent bioactivities, fifteen new pyrazole oxime ethers were designed and synthesized by introducing 1,3,4-oxadiazole moiety into the C-4 position of pyrazole based on the structure of fenpyroximate. Their structures were confirmed by 1 H NMR, 13 C NMR and elemental analysis. Preliminary bioassay data showed that some title compounds possessed good insecticidal activities against Oriental armyworm or Aphis medicaginis at the concentration of 500 and 100 μg/mL. At 100 μg/mL, compounds 10 a, 10 e, 10 f and 10 j displayed 100% mortality rate against Oriental armyworm, and compounds 10 g, 10 j and 10 l showed insecticidal activity against Aphis medicaginis with 100%. In addition, compound 10 l had 100% mortality rate against Tetranychus cinnabarinus at 500 μg/mL.
作者
王杨
叶浩
钱程
姚炜
李宏
王凯
胡兰萍
李玲
吴锦明
戴红
Wang Yang;Ye Hao;Qian Cheng;Yao Wei;Li Hong;Wang Kai;Hu Lanping;Li Ling;Wu Jinming;Dai Hong(College of Chemistry and Chemical Engineering,Nantong University,Nantong 226019;Nantong Fengtian Chemical Industry Co.Ltd,Nantong 226005)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第1期232-238,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21372135)
南通市科技计划(No.MS12017022-4,MS12019060)
和江苏省大学生创新训练计划(No.201810304016Z)资助项目。
关键词
1
3
4-噁二唑
吡唑肟醚
合成
杀虫活性
1,3,4-oxadiazole
pyrazole oxime ether
synthesis
insecticidal activity
作者简介
Corresponding authors:胡兰萍,E-mail:hlp@ntu.edu.cn;Corresponding authors:戴红,E-mail:daihong_2015@aliyun.com。
